Effect of Maternal Multiple Micronutrient Supplementation From Preconception Through Lactation on Child Growth and Development in Rural Pakistan: A Follow-up Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Full scale IQ score
研究概览
简要总结
The goal of this observational study is to learn about the long-term effects of maternal multiple micronutrient supplementation from preconception through to lactation on child neurodevelopment and growth in a resource-limited setting where there is a high burden of malnutrition. The main questions it aims to answer are:
- Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child neurodevelopment?
- Does maternal multiple micronutrient supplementation from preconception through to lactation compared to the standard of care have an effect on child growth?
This is a cross-sectional follow up study to a substudy of breastmilk composition and infant growth within the Matiari emPowerment and Preconception Supplementation (MaPPS) Trial, wherein mothers were randomized to receive a multiple micronutrient supplement from preconception through to lactation or the standard of care (ClinicalTrials.gov Identifier: NCT04451395).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 4 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Child participated in the MaPPS Trial Breastmilk Sub-study at 3-months of age
- •Child has reached their fourth birthday
- •Child is available in the study catchment area (Matiari District)
排除标准
- 未提供
结局指标
主要结局
Full scale IQ score
时间窗: At 4 years of age
Wechsler Preschool and Primary Scale of Intelligence (WPPSI), minimum score: 40 and maximum score: 160 (higher scores mean a better outcome)
次要结局
- Fine and gross motor skills score(At 4 years of age)
- Height(At 4 years of age)
- Head circumference(At 4 years of age)
研究者
Deborah O'Connor
Chair, Department of Nutritional Sciences
University of Toronto