A comparative study of intravenous clonidine versus esmolol for attenuation of hemodynamic response associated with laryngoscopy and intubation in abdominal surgeries under general anaesthesia: A randomised double blind interventional study at sms hospital jaipur during year 2109-20
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- 1-Mean heart rate
研究概览
简要总结
In this study we aim to compare the efficacy of intravenous clonidine (1 micro gram/kg body weight) versus intravenous esmolol (1mg/kg body weight) for attenuation of hemodynamic response associated with laryngoscopy and Intubation in abdominal surgeries under general anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade 1 & A2 Elective abdominal surgeries.
排除标准
- •1-Unwilling to participate in study 2-patient with difficult airway 3-patient known allergic to test drug 4-history of medication affecting heart rate and blood pressure 5-heart rate less than 60 6-bleeding disorder.
结局指标
主要结局
1-Mean heart rate
时间窗: Hemodynamic variables at | 1- base line | 2-before study drug | 3-after study drug | 4-before incubation | 5- 1minute 3 minute 5 minute and 10 minute post Intubation
2-Mean systolic blood pressure
时间窗: Hemodynamic variables at | 1- base line | 2-before study drug | 3-after study drug | 4-before incubation | 5- 1minute 3 minute 5 minute and 10 minute post Intubation
3-Mean diastolic blood pressure
时间窗: Hemodynamic variables at | 1- base line | 2-before study drug | 3-after study drug | 4-before incubation | 5- 1minute 3 minute 5 minute and 10 minute post Intubation
4-Mean arterial blood pressure
时间窗: Hemodynamic variables at | 1- base line | 2-before study drug | 3-after study drug | 4-before incubation | 5- 1minute 3 minute 5 minute and 10 minute post Intubation
次要结局
- Side effects(post operative side effects)