Comparison of dexmedetomidine and midazolam as adjuvants to 0.75% isobaric ropivacaine spinal anaesthesia in lower limb surgeries
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Onset and duration of sensory and motor block
研究概览
简要总结
Spinal anaesthesia is the commonly employed anaesthetic technique for lower limb surgeries. But it’s limitation is short duration of analgeisa. In order to extended the duration of block a number of agents are added along with local anaesthetic for spinal anaesthesia. Dexmedetomidine and midazolam are two such additives for spinal anaesthesia. In the present study we intend to compare dexmedetomidine and midazolam when added to spinal anaesthesia with 0.75% ropivacaine spinal anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18-60 years.
- •American Society of Anaesthesiologists (ASA) Grade I and II.
排除标准
- •Patient refusal for subarachnoid block 2)Known allergy to the study drugs 3)Infection at the puncture site 4)Coagulation disorders 5)Neurological disorders 6)Hepatic and renal disorders 7)Use of antipsychotic medications 8)Body mass index ≥ 30kg/m2 9)Pregnancy & lactation 10)ASA ≥ III.
结局指标
主要结局
Onset and duration of sensory and motor block
时间窗: 1)Onset of motor and sensory block will be assessed every 3min for the first 15 min after spinal anaesthesia. | 2) Duration of motor and sensory block will be assessed at the end of surgery in the post operative period.
次要结局
- Haemodynamic stability(Duration of analgesia)