TCTR20200708006已完成3 期
Efficacy of Olanzapine 5 mg versus 10 mg for the Prophylaxis of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving High Emetic Risk Chemotherapy,without Neurokinin-1 Receptor Antagonist
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- one
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •1. Age ≥ 18 year-old
- •2. Receiving the first cycle of doxorubicin/cyclophosphamide or high-dose cisplatin (≥70mg/m2)
- •3. Eastern Cooperative Oncology Group performance status 0 to 2
- •4. Adequate organ function (absolute neutrophil count ≥2000 cell/uL, aminotransferase < 100 IU/L, total bilirubin<2.0 mg/dl and creatinine clearance >50 ml/min)
排除标准
- •1. Symptomatic Brain Metastasis
- •2. Pregnancy or Breast-feeding
- •3. Allergy to agents in the study
- •4. Receiving anticonvulsants or fluoro-quinolone antibiotic
- •5. History of receiving NK-1 RA, 5-HT3 receptor antagonists, dexamethasone, dopamine receptor antagonists, antihistamines, benzodiazepine and antipsychotics in 48-hour, previously
- •6. Receiving abdominal radiotherapy
- •7. History of heart disease or arrhythmia or uncontrolled heart failure or acute myocardial infarction in 6 months previously or uncontrolled diabetes
研究者
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