NCT00919360终止不适用
Expression of Vascular Endothelial Growth Factor and Its Effectors in Preeclampsia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Relative pattern of expression in cases and matched controls of a robust set of genes in the VEGF/sFLT mediated model for preeclampsia in the placenta and decidua
研究概览
简要总结
The purpose of this study is to figure out some of the differences in bodily function between women who have preeclampsia and those who do not.
- This may eventually lead to an understanding of its cause. At this time, there is no known way to prevent preeclampsia, and the cause is not known.
- The only treatment is delivery of the baby, even if it is premature, in order to decrease the risk to the mother.
详细描述
- Preeclampsia is a pregnancy-related disorder that occurs in about 6% of all pregnancies.
- In its mild for, preeclampsia involves high blood pressure. More severe forms of preeclampsia can lead to more serious pregnancy complications.
- At this time, there is no known way to prevent preeclampsia, and the cause is not known. The only treatment is delivery of the baby, even if it is premature, in order to decrease the risk to the mother.
- The purpose of this study is to figure out some of the differences in bodily function between women who have preeclampsia and those who do not. This may eventually lead to an understanding of its cause.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Gravidas at 32-42 weeks gestation,who have preeclampsia as defined by Sibai et al,
- •Control patients: Gravidas without history of hypertension of any kind, and matched to cases for parity, gestational age, labor status, maternal age, and race.
排除标准
- •Prior betamethasone administration, fetal growth restriction (<3%ile), prior chronic hypertension (nonpregnant or < 20 weeks gestation any pregnancy), chorioamnionitis, major fetal anomaly or chromosome abnormality, multiple gestation, and maternal diabetes (any class except diet-controlled gestational).
结局指标
主要结局
Relative pattern of expression in cases and matched controls of a robust set of genes in the VEGF/sFLT mediated model for preeclampsia in the placenta and decidua
时间窗: 1- 2 years
次要结局
- Determine the population variance for each gene of interest(1 - 2 years)
- From this expression pattern,determine the validity of 18s ribosomal subunit as an endogenous control in this tissue.(1- 2 years)
- Using relative expression analysis in an embedded set of control subjects, determine whether common variables e.g. labor, parity independently influence expression of these genes of interest in the tissues studied(1 - 2 years)
研究者
Monique Ho
Assistant Professor
University of Florida
研究点 (1)
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