Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial - Adjuvant Steroids in Adults with Pandemic Influenza

ottingham University Hospitals NHS Trust0 个研究点目标入组 2,200 人开始时间: 2013年8月15日最近更新: 2019年6月30日

适应症

试验速览

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•This trial will be activated in the event of a pandemic. Trial activation will be decided by the NIHR in close discussion with the Trial Steering Committee, the Chief Investigators of the 8 NIHR Pandemic Portfolio studies and the Department of Health. The following inclusion criteria will apply when the trial is activated:
•During an influenza pandemic, patients are eligible for the entry into the trial if they:
•1)are aged = 16 years
•2)have been admitted to hospital within the previous 24 hours with a clinical diagnosis of an influenza-like illness and
•3)have given consent
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 50
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 1450
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 700

•Patients are not eligible for the study if ANY of the following apply at the time of admission to hospital:
•1)known to be taking oral or intravenous corticosteroid treatment
•2) require treatment with oral or intravenous corticosteroids upon admission to hospital as standard treatment for comorbid illness.
•3) known to be on insulin or oral medication for the treatment of diabetes mellitus
•4) known contra-indication to dexamethasone or any of the excipients

发起方

ottingham University Hospitals NHS Trust