Management in Real-life of Patients Hospitalized With Community-acquired Pneumonia in China
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- treatment failure at 72h after initiation of antibiotics
研究概览
简要总结
The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and healthcare-associated pneumonia (HCAP) in real life of China .
详细描述
In China, the data about current management of patients hospitalized with CAP in the real-life setting is not available,type of pneumonia, selection of initial antibiotic, time to clinical stability, antibiotic choice anf modification,clinical outcomes and costs remain unclear.
In this study, we will collect comprehensive information on CAP and HCAP management patterns to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China .to analyze microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of patients with CAP (> and = 65 years, different comorbidities ,risk factors) ,to investigate microbiological characteristics,clinical manifestations,antibiotic regimens ,adherences to guidelines and effect on outcome in different groups of disease severity with CAP ,to provide the difference on microbiological characteristics,clinical manifestations,antibiotic regimens ,and outcome between patients with CAP and HCAP ,to understand the current situation of antibiotic regimen ,to evaluate influence of different antibiotic regimens on prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients > or = 14 years of age
- •Patient meets the criteria of community acquired pneumonia
- •Patient meets the criteria of healthcare-associated pneumonia
排除标准
- •Patients <14 years of age
- •Patient meets the criteria of hospital acquired pneumonia
- •Known active tuberculosis or current treatment for tuberculosis
- •Non-infectious pulmonary diseases
- •HIV positive
结局指标
主要结局
treatment failure at 72h after initiation of antibiotics
时间窗: Time from the first dose use of antibiotics to 72 hours
treatment failure was defined as a change of antibiotics due to worsening signs or symptoms associated with pneumonia
in-hospital treatment failure due to multiple causes
时间窗: Time from date of admission to discharge up to 1 week
1)death in hospital;2)change of antibiotics due to worsening signs or symptoms of infection, 3) recurrence, defined as signs or symptoms of infection after completion of therapy requiring re-initiation of antibiotics
次要结局
- in-hospital mortality(2 weeks)
- Duration of intravenous antimicrobial therapy(2 weeks)
- Hospital length of stay(2 weeks)
研究者
Bin Cao
MD
Capital Medical University