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临床试验/NCT03486847
NCT03486847已完成不适用

Postoperative Atelectasis in Pediatric Patients With Prone Position : Effect of Repetitive Alveolar Recruitment by Lung Ultrasound

Seoul National University Hospital2 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2018年3月29日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
74
试验地点
2
主要终点
Incidence of pre-extubation atelectasis

研究概览

简要总结

This study evaluates the incidence of postoperative atelectasis after general anesthesia with prone position using lung ultrasound in children age < 3 years.

详细描述

Atelectasis is common in pediatric patients after general anesthesia. Particularly, infants are more likely to develop atelectasis or ventilation-perfusion imbalance after general anesthesia because of the immature ribs and respiratory muscles, the high compliance of the rib cage and a significant reduction in functional residual capacity (FRC) during general anesthesia. Previous studies have reported that alveolar recruitment and positive end-expiratory pressure (PEEP) can be used to reduce atelectasis in children. Also, previous studies have shown that the lung ultrasound can be used to evaluate the degree of atelectasis during general anesthesia in children.

However, none of the previous studies investigated the incidence of atelectasis, the effect of alveolar recruitment, and the PEEP in pediatric patients under general anesthesia with prone position. The purpose of this study was to evaluate previously described parameters using lung ultrasound.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
None

入排标准

年龄范围
— 至 3 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Children undergoing general anesthesia with prone position
  • Endotracheal intubation and mechanical ventilation during general anesthesia
  • Operation time is more than 2 hours

排除标准

  • Previous lung surgery
  • Any abnormal findings such as atelectasis, pneumothorax, pleural effusion, or pneumonia on preoperative chest X-ray
  • Researchers judge (to be inappropriate)

结局指标

主要结局

Incidence of pre-extubation atelectasis

时间窗: postoperative 10 minutes

Incidence of pre-extubation atelectasis accessed by lung ultrasound

次要结局

  • Incidence of intraoperative hypotension(intraoperative)
  • Incidence of intraoperative and postoperative (within 12hr) desaturation(intraoperative and postoperative (within 12hr))
  • Incidence of intraoperative atelectasis after intubation(intraoperative)
  • Incidence of intraoperative atelectasis after position change to prone(intraoperative)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hee-Soo Kim

Professor

Seoul National University Hospital

研究点 (2)

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