Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Differential gene expression
研究概览
简要总结
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged greater than 20 years
- •Undergoing aortic valve surgery with or without CABG surgery
- •Receive and apical vent as part of the surgery
排除标准
- •Will not receive an apical left ventricular vent
结局指标
主要结局
Differential gene expression
时间窗: Immediate
次要结局
未报告次要终点
研究者
Jochen Daniel Muehlschlegel, MD
Associate Professor of Anesthesia
Brigham and Women's Hospital
