The effectiveness of simvastatin compared to atorvastatin: an e-clinical randomised feasibility trial within a research database in routine clinical practice

niversity of Liverpool (UK)0 个研究点目标入组 300 人开始时间: 2009年12月9日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•1. Aged 40 years or over, either sex
•2. Able and willing to provide informed consent to study participation
•3. Fully registered with the general practice for at least 6 months (i.e. subjects who are newly registered with the practice will not be eligible)
•4. Subjects who had not been prescribed a statin previously
•5. Subjects who in the opinion of the GP Investigator should be prescribed a statin
•6. Subjects who in the opinion of the GP Investigator have primary hypercholesterolaemia (cholesterol of 5.0 mmol/l or above) and have not responded adequately to diet or other appropriate measures (i.e. one of licensed indications of statins)
•7. Subjects who in the opinion of the GP Investigator would require a statin for primary prevention according to the 2008 NICE guideline on lipid modification: adults over 40 who have a 20% or greater 10-year risk of developing cardiovascular disease, based on Framingham 1991 10-year risk equations and clinical judgement
•Further details can be found in the British National Formulary (section 2.12) and in the 2008 NICE guideline on lipid modification [5], which will be available on the study website.

•Statins are contra-indicated in active liver disease (or persistently abnormal liver function tests), in pregnancy (adequate contraception required during treatment and for 1 months afterwards) and breast-feeding. Further details can be found in the British National Formulary (section 2.12).

发起方

niversity of Liverpool (UK)