The Effects of Low Intensity Exercise in Hypobaric vs. Normobaric Normoxic and Hypoxic Conditions on Baroreflex Sensitivity, Physiological Responses and Cerebral Functions in Pilots.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Baro-reflex sensitivity
研究概览
简要总结
The main goal of this project is to investigate how low intensity cycling exercise (1.5W/kg, for 6 minutes) influences cerebral functions, such as: Cerebral blood flow, oxygenation, and other physiological variables in different normobaric and hypobaric hypoxic conditions.
详细描述
Subjects will bike at 1W/kg for 6 minutes at different simulated altitude level in the hypobaric chamber at the FAI in Dübendorf. Concentration performance also will be measured to better understand how hypobaric and hypoxia conditions may affect physiological responses, cerebral and cognitive functions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
盲法说明
No drug and no arm are used for this study. This is a clinical study, because subjects are exposed to hypoxic conditions.
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Study Indication
- •Male and Female subjects from 18 years to 40 years of age
- •Healthy volunteer
- •Signed Informed Consent after being informed
排除标准
- •Contraindications to the study intervention.
- •Define drugs, treatments or interventions not allowed during the study or for specific periods of time prior to the intervention,
- •Women who are pregnant or breast feeding,
- •Intention to become pregnant during the course of the study,
- •Known or suspected non-compliance, drug or alcohol abuse,
- •Previous problem with hypoxia or altitude exposure,
- •Known pathologies/diseases
- •Relevant medical disorders
- •Anemia or poor health
- •History of flight sickness
研究组 & 干预措施
No arm used
No drug use for this study. No arm used in this study. Subjects are exposed to hypoxic conditions (clinical study).
干预措施: Hypoxia (Other)
结局指标
主要结局
Baro-reflex sensitivity
时间窗: 6 minutes per record.
To test the strength of relationship between RR interval and systolic blood pressure in human. Measurement before and after low intensity exercise in each condition.
次要结局
- Concentration performance(4 minutes per test)
- EEG microstates(6 minutes per record)
- Heart rate variability (HRV)(6 minutes per record)
- Cerebral blood flow(6 minutes per record.)