NL-OMON45781已完成不适用
The effect of cold exposure on the glycaemic and insulinaemic responses to an oral glucose load - The effect of cold exposure on glucose tolerance
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Inclusion Criteria of healthy population (n<=16):;Signed informed consent.
- •White European.
- •Age 18 - 40 years at the start of the study.
- •BMI * 20 and < 30 kg/m2.;Inclusion criteria of impaired glucose metabolism population (n<=16):;Signed informed consent.
- •White European.
- •Male or female.
- •Women should be postmenopausal or use hormonal contraconceptives.
- •Age 30 * 75 years at the start of the study.
- •BMI * 25 and <35 kg/m2.
- •Generally healthy, no medication use that interferes with metabolism. If volunteers need medication (e.g. statin drugs, NSAIDs), it will be reviewed with the dependent physician on an individual basis.
- •Impaired fasting glucose (5.6 mM to 6.9 mM) and/or blood glucose values 7.8-11.0 mM 2h after glucose drink consumption during OGTT in screening, based on the criteria set by the American Diabetes Association.
排除标准
- •Healthy population exclusion criteria:;Smoking.
- •Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or *other).
- •Cold-acclimated, such as takes daily cold showers or baths, or works in a refrigerated environment, or visit of a place with cold climate (e.g. skiing holiday), within 1 month previous to the start of the study.
- •Unstable body weight (gain or loss > 5kg in last 3 months).
- •Currently undertaking a diet.
- •Hb <8.4 mmol/L.
- •Performs strenuous exercise on most days of the week.;Impaired glucose metabolism population exclusion criteria:;Smoking.
- •Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or *other).
- •Cold-acclimated, such as takes daily cold showers or baths, or works in a refrigerated environment, or visit of a place with cold climate (e.g. skiing holiday), within 1 month previous to the start of the study.
- •Unstable body weight (gain or loss > 5kg in last 3 months).
- •Currently undertaking a diet.
- •Men: Hb <8.4 mmol/L, Women: Hb <7.8 mmol/L. *
- •Performs strenuous exercise on most days of the week.
研究者
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