NCT03884426Unknown不适用
Genetic and Phenotypic Characteristics of Mitral Valve Prolapse
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 3
- 主要终点
- MVP defined by a superior displacement of at least 2 mm
研究概览
简要总结
Phenotypic characterisation of MVP by echocardiography in families. Identification of genes involved in MVP.
详细描述
After clinical identification of patients with MVP, doctors organize 1st degree relative familial screening. A comprehensive echocardiography was carried out along with clinical examination. All echo data were stored for off-line analysis by a sonographer in our Core-lab. Blood was sample at the time of echocardiography in adult patients for DNA analyses. Follow-up for mitral valve changes will be performed after 5 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients of any age
- •with typical mitral valve prolapse
- •relatives examined during familial screening
排除标准
- •Refusal of the patient
结局指标
主要结局
MVP defined by a superior displacement of at least 2 mm
时间窗: At Day 0
MVP defined by a superior displacement of at least 2 mm
次要结局
- Comprehensive mitral valve apparatus characterization per size of items (leaflets, chordae, annulus)(At Day 0)
- Comprehensive mitral valve apparatus characterization per other items (papillary muscle, ventricles)(At Day 0)
- Comprehensive mitral valve apparatus characterization per size of items (ventricle and atrium sizes)(At Day 0)
- Comprehensive mitral valve apparatus characterization per size of items(At Day 0)
研究者
研究点 (3)
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