Association Between Troponin I Levels and Mortality Among Patients Undergoing Acute High-risk Abdominal Surgery - a Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 341
- 试验地点
- 1
- 主要终点
- The incidence of MINS within the first four postoperative days
研究概览
简要总结
The goal of this prospective cohort study is to estimate the incidence of myocardial injury after non-cardiac surgery (MINS) in patients undergoing acute high-risk abdominal surgery.
MINS is defined as at least one increased single measurement of plasma troponin I (TnI). TnI-dynamic is defined as either two succeeding measurements of TnI > 59 ng/l with an increase/fall of more than 20%, or by one measurements of TnI > 59 ng/l with a succeeding measurement of TnI < 59 ng/l and a decrease of more than 50%.
Participants will have plasma TnI measured 6-12 hours postoperatively and on each of the following four postoperative days. Follow-up will be minimum one year after surgery.
The aim of the study is to determine:
- The incidence of MINS within the first four postoperative days
- The incidence of dynamic TnI changes
- The association between MINS and dynamic TnI changes respectively and all-course short-term mortality
详细描述
Gastrointestinal tract perforation, bowel ischemia and bowel obstruction are considered acute high-risk abdominal disorders, often requiring emergency surgery. Myocardial injury after non-cardiac surgery (MINS) is a frequent but often unrecognized postoperative complication. MINS is associated with an increased risk of other cardiac complications and 30-day mortality. However, the literature on MINS is mainly regarding patients undergoing a wide range of elective or acute surgical procedures, and we do not know if the dynamic TnI-criteria used for acute myocardial injury has any association with mortality in patients with MINS.
This study aims to estimate the incidence of MINS in patients undergoing AHA surgery, and the association between the short-term mortality and MINS defined as a single increased measurement of TnI and as TnI dynamics respectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •Patients undergoing acute high-risk abdominal surgery
排除标准
- •Patients with microscopic perforations in colonic diverticulitis managed with laparoscopic lavage or drainage
- •If further treatment postoperatively was assessed as futile and terminated immediately after surgery
结局指标
主要结局
The incidence of MINS within the first four postoperative days
时间窗: The first four postoperative days
Postoperative troponin I level equal to or above 59 ng/L
次要结局
- The incidence of dynamic plasma Troponin I changes(The first four postoperative days)
研究者
Charlotte Tiffanie Bendtz Kanstrup
PhD, MD
Nordsjaellands Hospital