Exercise in the Fasted State, Glucose Metabolism and Energy Balance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Exogenous glucose appearance rate
研究概览
简要总结
The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Individuals free from known cardiovascular, metabolic or joint disease as determined by standard health questionnaire.
- •Habitual regularly participating in exercise (minimum of 3 sessions per week on average)
- •Non-smoker
排除标准
- •Known or suspected food intolerances, allergies or hypersensitivity.
- •Any bleeding disorder or taking medication which impacts blood coagulation.
- •Known tendency towards keloid scarring.
- •Known sensitivity or allergy to any local anaesthetic medicines.
- •Any reported use of substances which may pose undue personal risk to participants or introduce bias into the experiment.
- •Any other condition or behaviour deemed either to pose undue personal risk to participants or introduce bias into the experiment.
研究组 & 干预措施
Breakfast Exercise
干预措施: Exercise (Behavioral)
Breakfast Exercise
干预措施: Breakfast (Dietary Supplement)
Fasted Exercise
干预措施: Exercise (Behavioral)
Breakfast Rest
干预措施: Breakfast (Dietary Supplement)
结局指标
主要结局
Exogenous glucose appearance rate
时间窗: 120 minutes
Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).
Energy balance
时间窗: 24 hours
Energy balance (intake minus expenditure) over 24 h from the beginning of the trial
次要结局
- Glucose clearance rates(120 minutes)
- Endogenous glucose appearance rates(120 minutes)
- Energy intake(24 h)
- Exogenous glucose appearance rates(120 minutes)
- Energy expenditure(24 h)
研究者
Javier Gonzalez
Lecturer
University of Bath