Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl for Correction of Hypokalemia in Hospitalized Patients
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 84
- 试验地点
- 2
- 主要终点
- Number of participants with normal serum K as assessed by serum electrolyte
研究概览
简要总结
evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia
详细描述
Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia.
Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Serum K+ 2.5-3.49 mmol/L
- •No life threatening condition from hypokalemia
排除标准
- •Pregnancy
- •Volume overload, heart failure
- •Hypotension
- •Acute kidney injury
- •Dysnatremia
- •Salt wasting nephropathy
结局指标
主要结局
Number of participants with normal serum K as assessed by serum electrolyte
时间窗: 24 hours
次要结局
未报告次要终点