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临床试验/NCT03846388
NCT03846388已完成不适用

Prediction Of Reproductive Outcome in Assisted Conception Cycles in Women With Unexplained Infertility

Assiut University2 个研究点 分布在 1 个国家目标入组 292 人开始时间: 2019年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
292
试验地点
2
主要终点
live birth rate

研究概览

简要总结

Infertility is the failure to conceive after regular unprotected sexual intercourse for one year. Primary infertility refers woman who has never conceived, and secondary infertility to one who has had a previous pregnancy.The most frequent causes for infertility are ovulatory disorder or anovulation (27-30%) , tubal factor(20-22%), abnormal semen parameters(45-50%). Unexplained infertility refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency tests and semen analysis are normal. incidence 15-17% of infertile couples. New guidelines on infertility recommend that women with unexplained infertility should be advised for expectant management for 2 years .If pregnancy is not achieved after this period In vitro fertilization Should be considered. The Fast Track and Standard Treatment trial demonstrated A shorter time to pregnancy and higher per cycle pregnancy rates for In vitro fertilization compared with treatment with oral agents or gonadotropins in Patients with unexplained infertility. Successful pregnancy after assisted reproductive technology is influenced by numerous predictors that have been investigated in the previous years. The central predictors of success are the sperm, oocyte quality and endometrial receptivity. Oocyte quality depends mainly on the age of the woman , and her ovarian reserve. Parameters most commonly studied are the woman's age , her antral follicle count , and laboratory tests including serum randomly done during the menstrual cycle levels at day 3 of the cycle.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • in vitro fertilization treatment due to many factors including tubal, male, and unexplained factors.
  • body mass index (BMI) (18-35)kg/m2
  • Exclusion Criteria
  • patient age less than 20 and more than 40 years.
  • body mass index less than 18 and more than 35 kg/m
  • period of infertility less than 2 years..
  • untreated hyperthyroidism, hypothyroidism, diabetes, hypertension.

排除标准

  • 未提供

结局指标

主要结局

live birth rate

时间窗: 12 months

次要结局

  • Number of fertilized oocytes(3 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohammed Khairy Ali

lecturer

Assiut University

研究点 (2)

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