Ketone Levels Achieved After Medium Chain Triglyceride (MCT) Oil
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Maximum plasma concentration (Cmax)
研究概览
简要总结
Assessing Ketone levels achieved after varying doses of Medium Chain Triglyceride (MCT) oil
详细描述
Assessing Ketone levels achieved after varying doses of Medium Chain Triglyceride (MCT) oil in three study populations: <65 year healthy, 65 and older healthy, and Alzheimer's disease.
Each subject attends for 4 study days, receiving incrementally larger MCT doses at each visit for 0g, to 14g, to 28g to 42g.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adult, healthy or with AD
排除标准
- •unable to attend all study days
- •coconut allergy
研究组 & 干预措施
Healthy, under 65 years
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter (All MCT doses administered as a single dose at time 0)
干预措施: Medium Chain Triglyceride oil (Dietary Supplement)
Healthy, over 65 years
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter.
(All MCT doses administered as a single dose at time 0)
干预措施: Medium Chain Triglyceride oil (Dietary Supplement)
Alzheimer's Disease subjects
Four study days. Day 1 administered 0g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 2 administered 14g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 3 administered 28g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter Day 4 administered 42g MCT oil with baseline and hourly betahydroxybutyrate (BHB) measures (by fingerstick test) for 5 hours thereafter.
(All MCT doses administered as a single dose at time 0)
干预措施: Medium Chain Triglyceride oil (Dietary Supplement)
结局指标
主要结局
Maximum plasma concentration (Cmax)
时间窗: 3 months
Calculation of Cmax to varying doses in each subject and in different study arms.
Area under the curve (AUC)
时间窗: 3 months
Calculation of AUC to varying doses in each subject and in different study arms.
Time to maximum plasma concentration (tmax)
时间窗: 3 months
Calculation of tmax to varying doses in each subject and in different study arms.
次要结局
- Body fat(3 months)
- weight(3months)
- height(3 months)
- BMI(3months)