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临床试验/NCT06368271
NCT06368271已完成不适用

Acute Effects of Dietary Medium-chain Fatty Acids on Llipid Profile

University of Copenhagen3 个研究点 分布在 1 个国家目标入组 4 人开始时间: 2021年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
4
试验地点
3
主要终点
Meal test including medium-chain fatty acids

研究概览

简要总结

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

详细描述

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
20 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • healthy males BMI:20-27 recreationally physical active non-smoker no medicine

排除标准

  • high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

结局指标

主要结局

Meal test including medium-chain fatty acids

时间窗: 0-4 hours

In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile

次要结局

  • Resting metabolic rate(0-4 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bente Kiens

Professor

University of Copenhagen

研究点 (3)

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