Comparison Between Ultra-low-dose Computed Tomography and Lung MRI for Morphological Assessment of Lung Disease in Adult Cystic Fibrosis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 185
- 试验地点
- 1
- 主要终点
- Reproducibility of visual score between imaging modalities
研究概览
简要总结
The purpose of this study is to compare the performances of ultra-low dose computed tomography (CT) and lung magnetic resonance imaging (MRI) for morphological assessment of cystic fibrosis-related lung disease and to compare their performances to conventional low dose CT
详细描述
Cystic fibrosis (CF) is a recessive autosomal disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes for an epithelial chloride channel involved in ion and fluid transport. CF is the most common inherited disease in Caucasians and disease severity mainly depends on the degree of lung involvement, which can lead to terminal respiratory failure Disease monitoring of CF-related lung disease rely on functional assessment and complimentary morphological assessment. Conventional low-dose chest computed tomography (CT) is currently the gold standard for the morphological assessment of CF-related lung disease but ultra-low dose chest CT and high-resolution magnetic resonance imaging (MRI) of the lung using UTE sequences have been recently developed and allow important radiation reduction of radiation dose exposure. However the performances of these 2 competing imaging methods remains to be compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 year-old
- •Diagnosis of cystic fibrosis provided by genetic and swear test
- •Chest CT acquisition performed as part of the standard follow-up
- •Patient with social security or health insurance
- •Informed consent
排除标准
- •MRI contraindication
- •Orthopnea
- •Inability to hold breath for 17 seconds
- •No spirometry planned the same day
- •Lung transplant patient
结局指标
主要结局
Reproducibility of visual score between imaging modalities
时间窗: 1 day
Reproducibility disease severity measured by the Helbich scoring system with conventional CT as gold standard
次要结局
- Correlation between visual scores and pulmonary function(1 day)
- Intra and interobserver reproducibility of visual scores(1 day)
- Correlation between air trapping at MRI and pulmonary function test(1 day)