Potential Beneficial Effects of Resveratrol on Obesity, Metabolic Syndrome and Inflammation - Emphasis on Description of the Molecular Biology Underpinning the Interplay Between Calorie Restriction, SIRT1, STAT5 and the GH/IGF-I Axis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Metabolic parameters
研究概览
简要总结
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
详细描述
The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI > 30 kg/m2
- •Otherwise healthy
- •Written informed consent
排除标准
- •Any disease
- •Alcohol dependency
- •Allergy to trial medication
- •Present or previous malignancy
- •Participation in other clinical trials within three months before randomization
研究组 & 干预措施
Placebo
干预措施: Placebo (Other)
Resveratrol
Dietary supplement of resveratrol 500 mg three times a day over five weeks.
干预措施: Resveratrol (Dietary Supplement)
结局指标
主要结局
Metabolic parameters
时间窗: Five weeks
Regarding glucose, protein and fat metabolism.
次要结局
- Pathways of substrate metabolism.(Five weeks)