Evaluating the effectiveness for pain reduction and organ failure improvement of continuous ropivacaine infusion via epidural catheter in acute pancreatitis

B?ch Mai Hospital0 个研究点目标入组 72 人开始时间: 2023年9月29日最近更新: 2023年10月30日

试验速览

暂无简介。

•1. Aged = 18 years.
•2. Diagnosis of acute pancreatitis required two of the following three features, as per the revised Atlanta definition: abdominal pain consistent with acute pancreatitis, serum lipase activity at least three times greater than the upper limit of normal, and characteristic findings of acute pancreatitis on contrast-enhanced computed tomography.
•3. Onset = 72 h.
•4. Pain moderate or severe with visual analog pain scale (VAS) = 4 in consciousness patients or behavioral pain scale (BPS) = 7 in unconsciousness patients.
•5. Classification is severe acute pancreatitis (modified Marshall score = 2 on admission) OR predicted severe (at least one of criteria: (1) Ranson's Criteria = 2 points; (2) CRP level > 100 mg/L; (3) Pancreatic necrosis on contrast-enhanced computed tomography.

•Patients fulfilling one or more of the following criteria were not included:
•1. Prothrombin time < 60%, platelet count < 75 G/L, curative anticoagulant therapy with heparin interrupted for less than 8 h
•2. Local infection
•3. Failed procedure
•4. Anaphylaxis history with ropivacaine, lidocaine, ropivacaine
•5. Local anesthetic systemic toxicity history
•6. Pregnancy

发起方

B?ch Mai Hospital