Combined Effects of Meal Frequency and Protein Load on Cardiometabolic Risk Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 主要终点
- Venous Plasma Insulin
研究概览
简要总结
This study examines the effect of meal frequency and meal composition on risk factors of cardiometabolic disease.
详细描述
Cardio-Metabolic Disease (CMD) is the leading cause of death globally & in Singapore. Large scale epidemiological evidence confirmed that elevated postprandial Glucose, Insulin, Triglycerides are major risk factors for CMD. Recent evidence suggests benefits from high protein diets but the health effects of eating smaller meals remain enigmatic. The aim of this study is to examine Meal frequency (2-large vs 6-smaller isocaloric meals), under High or Low Protein loads on acute postprandial health biomarkers . The investigators hypothesized that Higher Protein & Higher Meal Frequency would be beneficial for cardiometabolic health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Chinese Males
- •Age: 21 - 50 years.
- •Body mass stable within the last 2 months by self-report.
- •Body mass index (BMI): < 30kg/m
- •Normal fasting blood glucose level≤ 6.0 mmol/L
- •Blood pressure ≤ 140/90 mmHg
- •Not participating in any dietary interventions in the past 2-months.
排除标准
- •Special dietary practice (e.g. Vegetarians, Atkins diet) or diets due to religious reasons during the study period (e.g. Fasting for Ramadan)
- •Excessive alcohol consumption: consuming alcohol on >4 days per week with ≥5 alcoholic drinks (males) and ≥4 alcoholic drinks (females) per time (National Health Survey, 2010).
- •Metabolic Diseases (including thyroid dysfunction)
- •Using Medication affecting carbohydrate and fat metabolism
- •Allergy to any components of the provided meals (gluten, nuts, milk, dairy)
结局指标
主要结局
Venous Plasma Insulin
时间窗: Postprandially 8.5 hours in response to the various diets
Biochemical variable on a continuous scale.
Interstitial Glucose
时间窗: Postprandially 8.5 hours in response to the various diets
Measured using a continuous glucose monitor.
Venous Plasma Glucose
时间窗: Postprandially 8.5 hours in response to the various diets
Biochemical variable on a continuous scale.
Blood Pressure
时间窗: Postprandially 8.5 hours in response to the various diets
Systolic and Diastolic Pressure measured in mmHg
Venous Plasma Triglyceride
时间窗: Postprandially 8.5 hours in response to the various diets
Biochemical variable on a continuous scale.
次要结局
- Urinary F2 Isoprostanes(Postprandially 8.5 hours in response to the various diets)
- Subjective Appetite Ratings(Postprandially 8.5 hours in response to the various diets)
研究者
Melvin Leow
Principal Investigator
Clinical Nutrition Research Centre, Singapore