Comparison of Standardized Update Value Using Single-photo Emission Computed Tomography and Computed Tomography Between Grave's Disease (Hyperthyroidism) Patients and Normal Humans
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 9
- 主要终点
- The SUV values of GD patients and normal humans provided by Q.Metrix
研究概览
简要总结
The purpose of this study is to find out the capacity of standardized uptake value (SUV) using single-photo emission computed tomography and computed tomography (SPECT/CT) in diagnosing Grave's Disease (hyperthyroidism).
详细描述
Traditionally it is considered that only positron emission tomography(PET) has the ability to obtain standardized uptake value(SUV)while single-photo emission computed tomography(SPECT) does not have. Recently with the developing of technology, the ability of SPECT has been extended.
On the other hand, thyroid imaging by SPECT can only play an auxiliary role in hyperthyroidism diagnosis mainly since it is regarded as nonquantitative. So the investigators design this study to search the capacity and accuracy of SUV provided by SPECT and CT(CT is used for reconstruction algorithm) in diagnosing GD.
This is a multiple-center study containing nine groups in China that use GE Discovery NM/CT, an advanced equipment. Thus, the data can be more accurate and more available.
And this is a perspective clinical trial, taking about eight months. The investigators plan to evaluate at least 50 Grave's Disease(GD) patients and 50 normal humans as contrast in all.
Every GD patient must have been diagnosed and the results of thyroid function tests(such as TSH,FT3,FT4) must be available. If necessary, the patient's rate of iodine uptake should also be known before he/she being included in this study. As for normal people, the results of thyroid function tests should be within the range of normal value.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •certainly diagnosed with GD
- •no treatment
- •sign a informed consent
排除标准
- •Inflammatory Hyperthyroidism
- •Secondary Hyperthyroidism (since of medicine, thyrotrophs neoplasms and etc)
- •Can not finish the check of SPECT/CT
- •Refuse to sign a informed consent
- •For Group of Normal Humans:
- •Inclusion Criteria:
- •without GD
- •sign a reformed consent
- •Exclusion Criteria:
- •Without normal values of TSH, FT3, FT4
- •Can not finish the check of SPECT/CT
- •Failed to sign a reformed consent
结局指标
主要结局
The SUV values of GD patients and normal humans provided by Q.Metrix
时间窗: a single point in time, at subject enrollment
The data of thyroid fusion imaging will be processed by the software, Q.Metrix, which can get the accurate SUV by compensating for photon absorption within the body, removing scattered radiation and etc.
The thyroid imaging of GD patients and normal humans by SPECT/CT
时间窗: a single point in time, at subject enrollment
For GD patients and normal healthy volunteers, we will get the data of thyroid fusion imaging by giving them a SPECT/CT check at subject enrollment.
次要结局
未报告次要终点
研究者
Li Yuhao
Technologist, a graduated student of Department of Nuclear Medicine
West China Hospital
