NCT07184073已完成不适用
Association Between Cognitive Fraility and Blood and CSF Biomarkers in Older Orthopedic Patients Under Regional Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 129
- 试验地点
- 1
- 主要终点
- Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?
研究概览
简要总结
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery.
The main questions it aims to answer is:
- Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions?
- Can these biomarkers be used as potential tools for early identification in vulnarable populations?
详细描述
It is a cross sectional study
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA 1-3 patients
- •>65 age patients
排除标准
- •history of psychiatric or neurological disease
- •uncontrolled hypertension
- •alchohol dependence
- •renal failure
- •active liver disease
- •cancer-related or emergency surgery
- •unwillingness to participate
结局指标
主要结局
Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function?
时间窗: preoperatively and four weeks postoperatively
p\<0,05 was accepted as statistically significant
次要结局
未报告次要终点
研究者
ELVIN KESIMCI
prof. dr
Baskent University
研究点 (1)
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