Evaluation of Systemic Microvascular Reactivity After Ingestion of an Energy Drink in Young Male Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Endothelium-dependent skin microvascular reactivity
研究概览
简要总结
Purpose: Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. Their consumption is rising worldwide, with only few conflicting studies examining their vascular effects in young adults. We evaluated microvascular reactivity (MR) before and after ED in young healthy male volunteers.
Methods: Systemic MR was evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine (ACh) iontophoresis before, 90 and 180 minutes after the consumption of one can of ED or the same volume of water (control), followed by postocclusive reactive hyperemia (PORH).
详细描述
Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. These products are marketed as boosters of mental and physical performance and are increasingly used in Western societies. Case reports of adverse effects related to ED consumption have been described in healthy young individuals, including coronary artery vasospasm, and myocardial infarction. These data suggest that endothelial dysfunction (EDysf) plays a role in ED cardiovascular effects and have prompted studies with conflicting results. The present study evaluated the microvascular reactivity (MR) after ingestion of one can of ED compared to a control, in young healthy male volunteers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male volunteers with no relevant findings in the medical history
排除标准
- •being a competitive athlete;
- •being on regular medication;
- •using illicit drugs;
- •being allergic to coffee, taurine or any of the components of the selected energy drink; - -
- •having a body mass index ≥ 30 kg/m2.
结局指标
主要结局
Endothelium-dependent skin microvascular reactivity
时间窗: Microvascular reactivity will be evaluated after a 20-minute rest in the supine position in a temperature-controlled room.
Cutaneous microvascular flow measured with laser speckle contrast imaging
次要结局
未报告次要终点
研究者
Eduardo Tibirica, MD, PhD
Senior researcher
National Institute of Cardiology, Laranjeiras, Brazil