Energy Drinks and Vascular Function
- Conditions
- Vascular Function
- Registration Number
- NCT03324256
- Lead Sponsor
- University of Florida
- Brief Summary
The purpose of this study will be to examine the acute effect of commercially available energy products on endothelial function, arterial stiffness and thrombosis in healthy young males.
- Detailed Description
The use of energy products has significantly increased in the last few years and is especially high among young men. The present study will compare the acute effect of a commercially available energy drink, energy gum, coffee and control beverage on endothelial function, arterial stiffness and circulating markers of thrombosis, inflammation and oxidative stress.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 19
- Being Male
- 18-30 years of age
- No indication of major clinical disease (e.g. diabetes, hypertension, significant arrhythmias, syncope and cardiovascular disease)
- BMI ≤ 30 kg/m^2 and blood pressure ≤ 140/90 mmHg
- Consumption of <400mg of caffeine/day
- Prior history of consumption of energy drinks
Exclusion criteria:
- Being female
- Age <18 or >30 years
- BMI> 30 kg/m^2 and blood pressure > 140/90 mmHg
- Use of medication that may affect vascular measures
- Use of tobacco products including smoking
- Vegan or vegetarian diet
- Being energy drink or caffeine naïve or consumption of >400 mg of caffeine/day
- Consumption of >1 energy drinks per month
- Being a shift worker
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in endothelial function Before and 1 and 2 hrs following consumption of drink and gum Brachial artery flow-mediated dilation
- Secondary Outcome Measures
Name Time Method Change in arterial stiffness Before and 1 and 2 hrs following consumption of drink and gum Carotid to femoral pulse wave velocity
Change in heart rhythm Before and 1 and 2 hrs following consumption of drink and gum Electrocardiogram
Change in wave reflection Before and 1 and 2 hrs following consumption of drink and gum Augmentation index
Change in peripheral and central blood pressures Before and 1 and 2 hrs following consumption of drink and gum Brachial and aortic blood pressures
Change in thrombosis and platelet function Before and 1 and 2 hrs following consumption of drink and gum Thromboelastograph and platelet aggregation tests
Change in circulating factors related to vascular function Before and 1 and 2 hrs following consumption of drink and gum Circulating levels of Trimethylamine N-oxide (TMAO) and markers of oxidative stress and inflammation
Trial Locations
- Locations (1)
University of Florida
🇺🇸Gainesville, Florida, United States
University of Florida🇺🇸Gainesville, Florida, United States