Cleveland Clinic Opens Two New Research Buildings in Largest Research Investment in Its History
核心洞察
Cleveland Clinic opened two new research buildings totaling 300,000 square feet at E. 100th Street and Cedar Avenue, representing the largest research investment in the organization's more than 100-year history.
The facilities house more than 700 employees and nearly 30 laboratories and core service areas, including the Sheikha Fatima bint Mubarak Global Center for Pathogen & Human Health Research (搜索).
The $400 million complex anchors the $500 million Cleveland Innovation District, a public-private initiative targeting 20,000 jobs and $3 billion in regional economic impact by 2030.
Cleveland Clinic has officially opened two new state-of-the-art research buildings at E. 100th Street and Cedar Avenue, marking the largest research investment in the organization's more than 100-year history. The $400 million expansion adds roughly 300,000 square feet of laboratory space to the Main Campus footprint, bringing nearly 30 laboratories and more than 700 employees under one expanded research umbrella.
The twin facilities, connected by a skyway bridge over East 100th Street, split their space between a 170,000-square-foot northeast building and a 120,000-square-foot northwest building. The northeast structure houses the Sheikha Fatima bint Mubarak Global Center for Pathogen & Human Health Research (搜索), while the northwest building is dedicated to specialty research and core support services, according to Cleveland Clinic.
"We are grateful to the State of Ohio, JobsOhio, our Cleveland Innovation District partners and the many teams who made the opening of these new advanced research facilities possible," said Cleveland Clinic CEO and President Tom Mihaljevic, M.D. "These buildings will accelerate scientific discovery while strengthening Cleveland as a destination for healthcare, research and innovation."
The pathogen center's name traces back to a 2023 gift from the United Arab Emirates honoring H.H. Sheikha Fatima bint Mubarak, made to advance infectious disease (搜索), virology, and cancer (搜索) immunotherapy research. That gift also supports research facilities in Florida and an endowed chair, underscoring the international reach behind what is now a Main Campus centerpiece.
Designed for Collaboration and Computational Research
The buildings feature advanced research laboratories, open collaborative areas, classrooms, offices and a café, along with enhanced greenspace, landscaping and walking paths that create a new entrance to the southeast section of Main Campus.
"With these new facilities, we are creating a bold foundation for the next generation of scientific discovery and medical innovation," said Serpil Erzurum, M.D., Cleveland Clinic's Chief Research and Academic Officer. "The buildings are designed to bring scientists, clinicians and innovators together in an environment that accelerates collaboration, advances breakthrough scientific discovery, including high-performance computational research, and helps translate new ideas into better care for patients."
The new labs do not operate in isolation. Cleveland Clinic unveiled the IBM Quantum System One (搜索) at its Lerner Research Institute in March 2023, making it the nation's first private-sector, on-premises quantum computer dedicated to healthcare research under a 10-year Discovery Accelerator partnership. The system's processor was upgraded in late 2025 to support supercomputing research, giving the new laboratory space a computational partner already running on campus.
Anchoring the Cleveland Innovation District
The research complex serves as the primary anchor of the $500 million Cleveland Innovation District, a public-private initiative launched in January 2021 by the State of Ohio, JobsOhio, Cleveland Clinic, Case Western Reserve University, Cleveland State University, MetroHealth, and University Hospitals. Under that model, participating institutions are tasked with generating 20,000 direct and indirect jobs and contributing $3 billion to the Northeast Ohio regional economy by 2030.
Since the Cleveland Innovation District launched in 2021, Cleveland Clinic and anchor partners have made significant progress, exceeding many targets set by the Ohio Department of Development and JobsOhio. Over the past five years, Cleveland Clinic has created nearly 2,000 new jobs related to the district, exceeding the goal of 1,000 new full-time equivalency employees. More than 3,700 degrees and certificates have been supported through 129 educational programs.
Interim 2024 state reports showed partners had already created over 2,600 jobs and spent nearly $1.2 billion on research toward those 2030 targets.
Construction and Workforce Impact
Construction on the two buildings began in February 2023 under a Project Labor Agreement with the Cleveland Building and Construction Trades Council, an arrangement that generated approximately 400 jobs for local building trades members. The project's final steel beam, forming the East 100th Street skyway connecting the two buildings, was hoisted during a topping-off ceremony in August 2025.
The buildings were designed by Cleveland Clinic Buildings + Design in collaboration with HOK Architects & Vanderweil Engineers, with Gilbane Building serving as construction manager. The project was partially funded through philanthropic gifts.
A Broader Multi-Billion-Dollar Expansion
The research buildings are just one piece of a broader physical transformation underway across Cleveland Clinic's footprint. The health system's next major Main Campus milestone is a $1.1 billion, 1 million-square-foot Neurological Institute on Carnegie Avenue, with construction slated to finish by the end of 2026 and patient care beginning in early 2027. That facility is designed to consolidate inpatient and outpatient neurological services that had previously been scattered across campus.
Cleveland Clinic reported operating revenue of $18 billion and an operating margin exceeding 4% for fiscal year 2025, alongside nearly $500 million in efficiency savings — a financial footing that has fueled the broader building surge.
For now, the opening of the research complex marks a shift from cranes and steel beams to lab benches and computational research — the first tangible output of a project years in the making, even as the next billion-dollar phase of Cleveland Clinic's expansion is already rising nearby.