Impact of Hyperoxia During Cardiopulmonary
- Registration Number
- NCT02819739
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
The hypothesis implies that this work is the use of hyperoxia during cardiopulmonary bypass by his heart preconditioning effect is associated with a lower incidence of cardiac arrhythmias (atrial fibrillation, tachycardia or ventricular fibrillation) and lesions of myocardial ischemia-reperfusion injury in cardiac surgery postoperative.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 330
Inclusion Criteria
- Major patient ≥ 18 years
- Patient operated cardiac surgery for myocardial revascularization (CABG) or surgical correction of valvular or combined surgery (CABG and valve disease) or ascending aortic surgery
- Signed Consent
- Affiliation to social security
Exclusion Criteria
- Permanent atrial fibrillation
- Cordarone therapy,
- Pregnant woman
- Patient under guardianship or trusteeship or private public law
- Internal pacemaker
- Hypothermia,
- Patient refusal,
- Cardiac surgery without extracorporal circulation (ECC),
- Participation in another study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description normoxia medical oxygen During cardiopulmonary bypass inspired fraction of oxygen is adapted to maintained a oxygen arterial pressure below 150 mmHg. hyperoxia medical oxygen During cardiopulmonary bypass inspired fraction of oxygen is set to 100 %.
- Primary Outcome Measures
Name Time Method Occurred within 15 days after surgery, disorders of heart rhythm (atrial fibrillation, tachycardia or ventricular fibrillation) 15 days after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
CHU Dijon-Bourgogne
🇫🇷Dijon, France
CHU Amiens-Picardie
🇫🇷Amiens, France