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Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea

Oxygen Therapy in Diabetic Kidney Disease

Not Applicable
Not yet recruiting
Conditions
Diabetic Kidney Disease
Interventions
First Posted Date
2025-05-06
Last Posted Date
2025-05-06
Lead Sponsor
Assiut University
Target Recruit Count
80
Registration Number
NCT06959485
Locations
🇪🇬

Assuit University hospitals, Assiut, Egypt

Gut Microbiome Profiles in Patients with Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).

Phase 2
Recruiting
Conditions
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Paresthesia
Numbness
Tingling
Interventions
First Posted Date
2025-01-29
Last Posted Date
2025-02-12
Lead Sponsor
Bernardino Clavo, MD, PhD
Target Recruit Count
42
Registration Number
NCT06799351
Locations
🇪🇸

Hospital Universitario de Gran Canaria Dr. Negrín, (FIISC), Las Palmas, Spain

NASA Prebreathe Study

Phase 1
Recruiting
Conditions
Decompression Sickness
Interventions
Other: Altitude
First Posted Date
2024-12-18
Last Posted Date
2025-05-14
Lead Sponsor
Duke University
Target Recruit Count
12
Registration Number
NCT06740305
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Ozone Treatment in Paresthesia (numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy

Phase 2
Recruiting
Conditions
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Paresthesia
Numbness
Tingling
Interventions
First Posted Date
2024-11-26
Last Posted Date
2025-02-11
Lead Sponsor
Bernardino Clavo, MD, PhD
Target Recruit Count
42
Registration Number
NCT06706544
Locations
🇪🇸

Dr. Negrín University Hospital, Las Palmas, Spain

Effect of Topical Active Oxygen Therapy on Surgical Site Wound Healing and Microbial Colonization

Early Phase 1
Active, not recruiting
Conditions
Patients Scheduled for Any Oral Surgical Flap Procedure That Require Suturing Will Be Included in This Study
Interventions
First Posted Date
2024-11-26
Last Posted Date
2024-11-26
Lead Sponsor
Ain Shams University
Target Recruit Count
44
Registration Number
NCT06705920
Locations
🇪🇬

Faculty of Dentistry, Al Sherouk, Cairo, Egypt

Treatment of U.S. Veterans with Mild Traumatic Brain Injury with Hyperbaric Oxygen Therapy

Phase 1
Active, not recruiting
Conditions
Mild Traumatic Brain Injury
Hyperbaric Oxygen Therapy
Depression
Interventions
Device: Hyperbaric Oxygen Therapy Chamber
First Posted Date
2024-10-30
Last Posted Date
2024-10-30
Lead Sponsor
Nova Southeastern University
Target Recruit Count
40
Registration Number
NCT06665633
Locations
🇺🇸

Nova Southeastern University, Fort Lauderdale, Florida, United States

Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects

Not Applicable
Recruiting
Conditions
To Investigate Retinal Oxygen Extraction in Different Age Groups of Healthy Individuals
Interventions
First Posted Date
2024-10-16
Last Posted Date
2025-05-16
Lead Sponsor
Medical University of Vienna
Target Recruit Count
50
Registration Number
NCT06643403
Locations
🇦🇹

Department of Clinical Pharmacology, Medical University of Vienna, Austria, Vienna, Austria

Nitrous Oxide in the Treatment of Acute Suicidal Ideation

Phase 2
Recruiting
Conditions
Suicidality
EEG
Suicidal Ideation
Nitrous Oxide
Biomarkers / Blood
Biomarkers / Hair
Interventions
Drug: 50% N2O plus 50% O2
First Posted Date
2024-10-10
Last Posted Date
2025-01-16
Lead Sponsor
University of Zurich
Target Recruit Count
85
Registration Number
NCT06636357
Locations
🇨🇭

Psychiatric University Hospital Zurich, Zürich, Switzerland

Hyperbaric Oxygen Treatment for Veterans with Traumatic Brain Injury

Phase 3
Recruiting
Conditions
Traumatic Brain Injury
Military Operations
Interventions
First Posted Date
2024-08-30
Last Posted Date
2025-01-14
Lead Sponsor
University of South Florida
Target Recruit Count
420
Registration Number
NCT06581003
Locations
🇺🇸

University of South Florida, Tampa, Florida, United States

Hyperbaric Oxygen Therapy in HAMstring Injury (HOTHAM) Trial

Phase 3
Recruiting
Conditions
Hamstring Injury
Interventions
First Posted Date
2024-07-30
Last Posted Date
2024-11-20
Lead Sponsor
JL Tol
Target Recruit Count
50
Registration Number
NCT06526728
Locations
🇳🇱

Amsterdam UMC, Amsterdam, Noord-Holland, Netherlands

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