Impact of post-operative Lidocaine Infusion on GastroIntestinal Tract function in patients undergoing laparoscopic colorectal resections

Phase 3

• Conditions: Postoperative Ileus; Surgery - Other surgery; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12619001168145
• Lead Sponsor: Dr Rebecca Shine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-20
• Last Update Posted: 26 August 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

INCLUSION CRITERIA
All patients >18 years undergoing elective laparoscopic/hybrid colorectal resections for benign or malignant conditions at Austin hospital during the study period.

Exclusion Criteria

Contraindications to IV lidocaine:
•Known history of allergy or hypersensitivity to Lidocaine (lignocaine) or other amide-type local anaesthetic.
•Stokes-Adams syndrome or any type of heart block or other high-risk arrhythmias.
•Severe shock
•Myasthenia gravis
•Serious diseases of the CNS or of the spinal cord

Other exclusion criteria:
•Childs Pugh A or worse liver disease
•CKD with eGFR <40ml/hr
•Chronic use of opioid analgesia or local anesthetics
•Patients will be excluded if they were unable to participate in postoperative assessments because of language difficulty, postoperative confusion, or cognitive impairment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Return of Gastrointestinal Function - a composite outcome of: Time of first bowel motion and/or first flatus AND tolerating a solid meal<br>Designed specifically for this study. [Timepoint is the duration to return of gastrointestinal function this is checked every 2 hours by nursing staff, however the patient is also given a bowel function questionnaire and they are asked to complete this at the time of passage of flatus, bowel motion and tolerating solid diet. <br>These are checked daily and will continue to be checked daily until all three components have been completed. This will ususally be completed within 4 days from surgery ]