Does prenatal structural brain asymmetry predict later language localization and abilities?
- Conditions
- only healthy children will be investigatedhealthy volunteers
- Registration Number
- DRKS00010582
- Lead Sponsor
- Medizinische Universität Wien
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
an age of = 6 and = 16
normal neurological findings in fetal MRI and ultrasound
both parents native German speakers
good language comprehension and ability to follow instructions
intact vision and hearing
Exclusion Criteria
twin or multiple pregnancy
history of neurological or psychiatric disease general MR contraindication
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The queries regarding primary and secondary outcome do not apply to the present study. I the following, we specify the objectives of the study:<br><br>1) a positive correlation between prebirth structural lateralization of the planum temporale and childhood functional lateralization of language.<br><br>2) a positive correlation between prenatal structural asymmetry of the planum temporale and lateralization of language-related white matter bundles in childhood.<br><br>3) a correlation between prenatal anatomical asymmetry of the planum temporale and later language abilities, with a prenatal leftward asymmetry of the planum temporale significantly associated with better language abilities. <br><br>4) distributed markers beyond the asymmetry of the planum temporale that predict language functioning.
- Secondary Outcome Measures
Name Time Method The queries regarding primary and secondary outcome do not apply to this basic research of healthy children.