Fatigue after prophylactic cranial irradiation in stage I-III small cell lung cancer patients: is there a substrate on functional magnetic resonance imaging of the brain? - fatigue after prophylactic cranial irradiation

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 46 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Stage I-III SCLC:
•- Age >= 18 years
•- stage I-III SCLC pathology proven
•- Completed initial treatment with chemoradiotherapy, with at least stable disease (SD)
•- WHO PS <= 2
•- Ability to understand written questionnaires
•- Written informed consent;Stage III NSCLC:
•- Age >= 18 years
•- stage I-III NSCLC pathology proven
•- Completed treatment with chemoradiotherapy, with at least SD
•- WHO PS <= 2
•- Ability to understand written questionnaires
•- Written informed consent;Healthy controls:
•- Age >= 18 years
•- WHO PS <= 2
•- Ability to understand written questionnaires
•- Written informed consent

•- prior radiotherapy to the brain
•- claustrophobia
•- pregnancy
•- Metal implants or other contraindication for MRI
•- inability to lie supine for 30 minutes time (MRI)
•- antidepressants or steroids for the last two weeks
•- clinically relevant anemia (defined as Hb < 5.5 mmol/l)
•- chronic renal failure (defined as MDRD-eGFR < 30 ml/min/1.73m)
•- liver biochemistry abnormalities (defined as more than two times upper limit of normal)
•- major psychiatric illness requiring intervention in secondary care

发起方

Medisch Universitair Ziekenhuis Maastricht