Remote Ischaemic Preconditioning to Prevent Dialysis Induced Cardiac Injury
Phase 2
Terminated
- Conditions
- HemodialysisCardiovascular Diseases
- Registration Number
- NCT02630355
- Lead Sponsor
- Western University, Canada
- Brief Summary
This study evaluates the use of remote ischaemic preconditioning for the prevention of dialysis induced cardiac injury. The study uses four arms to test different frequencies of application to ascertain which, if any, is most successful at reducing dialysis induced cardiac injury.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- Patients having haemodialysis treatment at least 3 times per week at a London Health Sciences Centre facility
- Male and female, age≥16 years old.
Exclusion Criteria
- Not meeting inclusion criteria
- Exposure to haemodialysis for <90 days prior to recruitment
- Severe heart failure (New York Heart Association grade IV)
- Cardiac transplant recipients
- Mental incapacity to consent
- Declined to participate
- Taking cyclosporin
- Taking ATP-sensitive potassium channel opening or blocking drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The primary outcome will be a reduction in the number of left ventricular segments undergoing a greater than 30% reduction in longitudinal strain as detected by echocardiography at final study visit 4 weeks
- Secondary Outcome Measures
Name Time Method Change in Troponin-T, Plasma IL-6 and N-Type proBNP at intervention, first follow-up and final visit up to 4 weeks Number of segments undergoing >30% reduction in longitudinal strain at intervention, week 1, week 2 and week 3 visits up to 3 weeks Difference between pre and peak global longitudinal strain at intervention, week 1, week 2 and week 3 visits up to 3 weeks Change in pre-dialysis global longitudinal strain between baseline and final study visit between 1 and 4 weeks