A Study of Remote Ischaemic Preconditioning in Patients With Atherosclerosis Undergoing Vascular Surgery
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Abdominal Aortic Aneurysm
- Sponsor
- Tartu University Hospital
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- Carotide-femoral pulse velocity
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the effect of preoperative remote ischaemic preconditioning (RIPC) on organ damage and the functional characteristics of arteries in patients undergoing vascular surgery. In addition, we investigate the connection between RIPC and changes in the functional characteristics of arteries and low molecular weight metabolites.
Investigators
Jaak Kals
Clinic of Surgery, Department of Vascular Surgery, cardiovascular surgeon; MD-PhD
Tartu University Hospital
Eligibility Criteria
Inclusion Criteria
- •patients who are willing to give full informed consent for participation and
- •who are undergoing open abdominal aortic aneurysm repair or
- •who are undergoing endovascular aortic aneurysm repair or
- •who are undergoing lower limb revascularization surgery or
- •who are undergoing carotid endarterectomy
Exclusion Criteria
- •patients under age of 18
- •patients who are pregnant
- •patients with known malignancy during last 5 years
- •patients with permanent atrial fibrillation or flutter
- •patients with symptomatic upper limb atherosclerosis
- •patients who require home oxygen therapy
- •patients with eGFR \< 30 ml/min/1.73 m2, measured preoperatively
- •patients who have had myocardial infarction during last month
- •patients who have had upper limb vein thrombosis
- •patients who have undergone vascular surgery in the axillary region
Outcomes
Primary Outcomes
Carotide-femoral pulse velocity
Time Frame: 24 h
Measured with Sphygmocor XCEL * baseline characteristics are measured before surgery * measuring is repeated 24 h after surgery
Augmentation index
Time Frame: 24 h
Measured with Sphygmocor XCEL * baseline characteristics are measured before surgery * measuring is repeated 24 h after surgery
Secondary Outcomes
- Cardiac markers(24 h)
- Traditional biomarkers of renal function(24 h)
- Markers of inflammation and oxidative stress(24 h)
- Duration of hospital stay(30 days)
- Duration of intesive care unit stay(30 days)
- Cardiac event(10 days)
- Postoperative complications(10 days)
- 1- year mortality(1 year)
- Complications of remote ishcaemic preconditioning(10 days)
- Novel biomarkers of renal function(24 h)
- Estimated glomerular filtration rate(24 h)
- Low molecular-weight metabolites(24 h)
- Arterial elasticity indices(24 h)