Effect of Remote Ischemic Preconditioning on Platelet Activation During Cardiac Surgery With Cardiopulmonary Bypass
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Platelet Dysfunction
- Sponsor
- Seoul National University Hospital
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- Platelet activation measured by CD62P expression using flow cytometry
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
In this study, the investigators are going to investigate the effects of remote ischemic preconditioning on platelet activation in patients undergoing cardiac surgery with cardiopulmonary bypass.
Detailed Description
Previous studies reported that remote ischemic conditioning reduce platelet activation in patients with coronary artery disease or patients undergoing ablation for atrial fibrillation. Cardiac surgery with cardiopulmonary bypass has been associated with platelet activation. In this randomized study, investigators are going to compare the effects of remote ischemic preconditioning (RIPC) on platelet activation using flow cytometry in patients undergoing cardiac surgery with cardiopulmonary bypass.
Investigators
Yunseok Jeon
Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing cardiac surgery with cardiopulmonary bypass
Exclusion Criteria
- •Preoperative left ventricle ejection fraction \< 30%, mechanical ventricular support
- •Peripheral vascular disease
- •Poorly controlled diabetes mellitus
- •NSAIDs within 3 days
- •iv heparin within 6 h
- •low molecular weight heparin within 24 h
- •platelet inhibitor within 24 h
- •known thrombocytopenia
- •End stage renal disease / hemodialysis
- •Active infection
Outcomes
Primary Outcomes
Platelet activation measured by CD62P expression using flow cytometry
Time Frame: During 3hour after cardiopulmonary bypass initiation
CD62P AUC (area under the curve)
Secondary Outcomes
- ASPItest by Multiplate® platelet function analyser(3hour after cardiopulmonary bypass initiation)
- Platelet activation measured by platelet microparticles (PMP) expression using flow cytometry(During 3hour after cardiopulmonary bypass initiation)
- ADPtest by Multiplate® platelet function analyser(3hour after cardiopulmonary bypass initiation)
- COLtest by Multiplate® platelet function analyser(3hour after cardiopulmonary bypass initiation)
- Platelet activation measured by CD63 expression using flow cytometry(During 3hour after cardiopulmonary bypass initiation)
- Platelet activation measured by monocyte-platelet aggregates (MPA) expression using flow cytometry(During 3hour after cardiopulmonary bypass initiation)
- Platelet activation measured by PAC1 expression using flow cytometry(During 3hour after cardiopulmonary bypass initiation)