Effect of N-Acetylcysteine on moderate to severe traumatic brain injury patients

Not Applicable

Recruiting

• Conditions: Injury, Occupational Diseases, Poisoning; Nervous System Diseases

• Registration Number: PACTR202209548995270
• Lead Sponsor: Faculty of Pharmacy Damanhour University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-09-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1.Males or Females from 18 to 90 Years.
2.Hospital admission in the first 24 h of injury.
3.Moderate to severe traumatic brain injury (GCS score = 12)
4.The ability to tolerate enteral feeding.
5.Consenting guardian / relative.

Exclusion Criteria

1.Pregnant and breast-feeding women
2.Late presentation to hospital >24 hours.
3.Pre-existing hepatic failure.
4.Pre-existing renal failure.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
•Difference between the two groups in NSE levels on day 7

Secondary Outcome Measures

Name	Time	Method
•Difference between the two groups in S100B levels on day 7<br>•Difference between the two groups in MDA levels on day 7<br>•Difference between the two groups in IL-6 levels on day 7<br>•Glasgow coma scale (GCS)<br>