Evaluation of The Effect of N-acetylcysteine in The Prevention of Vancomycin-Induced Renal Disorder
Phase 3
- Conditions
- Vancomycin-Induced Nephrotoxicity.
- Registration Number
- IRCT20150721023282N3
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Treatment with Vancomycin for at Least 5 Days
Creatinine Clearance > 60 ml/min (Based on MDRD Formula)
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Creatinine. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Blood Urea Nitrogen. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Spectrophotometry.;Creatinine Clearance. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Cockroft - Gault Formula.;12-hour Urine Volume. Timepoint: At baseline and 2, 4, 6, 8, and 10 days after initiation of intervention. Method of measurement: Urine Bag.;The number of patients with acute kidney injury. Timepoint: End of intervention. Method of measurement: counting.
- Secondary Outcome Measures
Name Time Method