MedPath

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

Phase 3
Recruiting
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Other: Informational Intervention
Behavioral: Smoking Cessation Intervention
Other: Health Promotion and Education
Other: Questionnaire Administration
Registration Number
NCT05008848
Lead Sponsor
Alliance for Clinical Trials in Oncology
Brief Summary

This phase III trial compares the effect of text-based cessation intervention to a manual in helping rural cancer patients who smoke, quit. Text-based scheduled gradual reduction may reduce the frequency of cigarette use to zero and may be effective in quitting smoking.

Detailed Description

PRIMARY OBJECTIVES:

I. To evaluate the efficacy of an eight-week text-based scheduled gradual reduction (SGR) intervention (a personalized eight-week reduction schedule paired with National Cancer Institute's \[NCI's\] Smokefree.TXT) compared to a control intervention (NCI Clearing the Air Cessation Booklet) on biochemically-validated smoking cessation six-month post-quit date in rural cancer survivors.

SECONDARY OBJECTIVE:

I. Compare the efficacy of the eight-week text-based SGR intervention and a control intervention on Linear Analog Self-Assessment (LASA)-6 overall quality of life (QOL) at 30-days post-quit date and six-months post-quit date.

OUTLINE: Patients are randomized to 1 of 2 groups.

GROUP I: Patients participate in schedule gradual reduction program over 8 weeks to reduce the frequency of cigarette use. Patients also receive cessation support messages via text messages for 12 weeks.

GROUP II: Patients receive NCI's Clearing the Air booklet to help plan to gradually quit smoking.

After completion of study, patients are followed up at 6 months.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
600
Inclusion Criteria
  • Have a cancer diagnosis within the past 10 years, and can currently be receiving curative treatment
  • Not currently on hospice
  • Currently smokes >= 5 cigarettes daily
  • Lives in a nonmetro/rural county (defined as having a Rural Urban Continuum Code [RUCC] code of 4-9)
  • Patient interested in participating in a smoking cessation program, and not currently participating in a smoking cessation clinical trial
  • Not currently using any smoking cessation pharmacotherapy (e.g. nicotine replacement therapy, bupropion or varenicline), or currently participating in any cessation program
  • Patient has a cell phone or smart phone device with texting ability
  • In order to complete the mandatory patient-completed measures, participants must be able to speak and read English
  • Age >= 18 years
  • Participant must be willing to provide a urine sample.
Exclusion Criteria
  • Psychiatric illness which would prevent the patient from giving informed consent
  • Patients with impaired decision-making capacity are not eligible for this study.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Group I (SGR program, text messages)Health Promotion and EducationPatients participate in schedule gradual reduction program over 8 weeks to reduce the frequency of cigarette use. Patients also receive cessation support messages via text messages for 12 weeks.
Group I (SGR program, text messages)Questionnaire AdministrationPatients participate in schedule gradual reduction program over 8 weeks to reduce the frequency of cigarette use. Patients also receive cessation support messages via text messages for 12 weeks.
Group II (booklet)Informational InterventionPatients receive NCI's Clearing the Air booklet to help plan to gradually quit smoking.
Group I (SGR program, text messages)Smoking Cessation InterventionPatients participate in schedule gradual reduction program over 8 weeks to reduce the frequency of cigarette use. Patients also receive cessation support messages via text messages for 12 weeks.
Primary Outcome Measures
NameTimeMethod
Biochemically validated tobacco cessationUp to 6 months post-quit date

Response will be defined as (1) urine cotinine levels \< 50 ng/ml or (2) urine cotinine levels \>=50 ng/ml and an urine anabasine level \< 2 ng/ml if a patient self-reports vaping use or the use of nicotine replacement therapy (NRT). Patients who do not return at 6 months post-quit date for the cotinine assessment (and anabasine, if applicable) will be deemed non-responders. The analysis population is defined as all randomized and eligible patients. The primary evaluation of the primary outcome will be the covariate-adjusted intervention effect (adjusted odds ratio) obtained from a multiple logistic regression model adjusted for the three stratification factors baseline daily cigarette consumption, age, and sex as well as the potential confounding variables cancer diagnosis, cancer type, receipt of chemotherapy, receipt of radiation therapy, and active treatment.

Secondary Outcome Measures
NameTimeMethod
Serially measured overall quality of life (QoL) scores obtained at baseline and at 30-days and 6-months post-quite dateUp to 6-months post-quit date

At a given measurement time point, the patient-reported overall QoL score will be obtained from a linear analogue self-assessment scale (LASA), which is an 11-point scoring scale (0, 1, ..., 10) where 0 indicates as bad as can be and 10 indicates as good as can be. A linear mixed model will be used to compare the average difference between the randomized arms across the two post-randomization time points after adjusting for the baseline overall QoL score, the three stratification factors baseline daily cigarette consumption, age, and sex as well as the potential confounding variables cancer diagnosis, cancer type, receipt of chemotherapy, receipt of radiation therapy, and active treatment.

Trial Locations

Locations (191)

Saint Mary's Hospital

🇺🇸

Centralia, Illinois, United States

Kingman Regional Medical Center

🇺🇸

Kingman, Arizona, United States

Mercy Hospital Fort Smith

🇺🇸

Fort Smith, Arkansas, United States

Saint Helena Hospital

🇺🇸

Saint Helena, California, United States

Banner North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

Banner McKee Medical Center

🇺🇸

Loveland, Colorado, United States

Low Country Cancer Care

🇺🇸

Savannah, Georgia, United States

Memorial Health University Medical Center

🇺🇸

Savannah, Georgia, United States

Saint Alphonsus Cancer Care Center-Boise

🇺🇸

Boise, Idaho, United States

Saint Alphonsus Cancer Care Center-Caldwell

🇺🇸

Caldwell, Idaho, United States

Kootenai Health - Coeur d'Alene

🇺🇸

Coeur d'Alene, Idaho, United States

Saint Alphonsus Cancer Care Center-Nampa

🇺🇸

Nampa, Idaho, United States

Kootenai Clinic Cancer Services - Post Falls

🇺🇸

Post Falls, Idaho, United States

Kootenai Clinic Cancer Services - Sandpoint

🇺🇸

Sandpoint, Idaho, United States

Rush - Copley Medical Center

🇺🇸

Aurora, Illinois, United States

Illinois CancerCare-Canton

🇺🇸

Canton, Illinois, United States

Carle BroMenn Outpatient Center

🇺🇸

Bloomington, Illinois, United States

Illinois CancerCare-Bloomington

🇺🇸

Bloomington, Illinois, United States

Illinois CancerCare-Carthage

🇺🇸

Carthage, Illinois, United States

Decatur Memorial Hospital

🇺🇸

Decatur, Illinois, United States

SSM Health Good Samaritan

🇺🇸

Mount Vernon, Illinois, United States

Centralia Oncology Clinic

🇺🇸

Centralia, Illinois, United States

Crossroads Cancer Center

🇺🇸

Effingham, Illinois, United States

Carle BroMenn Medical Center

🇺🇸

Normal, Illinois, United States

Carle Cancer Institute Normal

🇺🇸

Normal, Illinois, United States

Cancer Care Center of O'Fallon

🇺🇸

O'Fallon, Illinois, United States

Carle at The Riverfront

🇺🇸

Danville, Illinois, United States

Cancer Care Specialists of Illinois - Decatur

🇺🇸

Decatur, Illinois, United States

Illinois CancerCare-Eureka

🇺🇸

Eureka, Illinois, United States

Illinois CancerCare-Kewanee Clinic

🇺🇸

Kewanee, Illinois, United States

Illinois CancerCare-Dixon

🇺🇸

Dixon, Illinois, United States

Illinois CancerCare-Galesburg

🇺🇸

Galesburg, Illinois, United States

Carle Physician Group-Effingham

🇺🇸

Effingham, Illinois, United States

Illinois CancerCare-Macomb

🇺🇸

Macomb, Illinois, United States

Carle Physician Group-Mattoon/Charleston

🇺🇸

Mattoon, Illinois, United States

Illinois CancerCare-Ottawa Clinic

🇺🇸

Ottawa, Illinois, United States

Illinois CancerCare-Pekin

🇺🇸

Pekin, Illinois, United States

Illinois CancerCare-Peoria

🇺🇸

Peoria, Illinois, United States

Illinois CancerCare-Peru

🇺🇸

Peru, Illinois, United States

Illinois CancerCare-Princeton

🇺🇸

Princeton, Illinois, United States

OSF Saint Anthony Medical Center

🇺🇸

Rockford, Illinois, United States

Southern Illinois University School of Medicine

🇺🇸

Springfield, Illinois, United States

Springfield Clinic

🇺🇸

Springfield, Illinois, United States

Springfield Memorial Hospital

🇺🇸

Springfield, Illinois, United States

Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

The Carle Foundation Hospital

🇺🇸

Urbana, Illinois, United States

Illinois CancerCare - Washington

🇺🇸

Washington, Illinois, United States

Rush-Copley Healthcare Center

🇺🇸

Yorkville, Illinois, United States

University of Iowa Healthcare Cancer Services Quad Cities

🇺🇸

Bettendorf, Iowa, United States

Saint Anthony Regional Hospital

🇺🇸

Carroll, Iowa, United States

Saint Luke's Hospital

🇺🇸

Cedar Rapids, Iowa, United States

Oncology Associates at Mercy Medical Center

🇺🇸

Cedar Rapids, Iowa, United States

Iowa Methodist Medical Center

🇺🇸

Des Moines, Iowa, United States

UI Health Care Mission Cancer and Blood - Des Moines Clinic

🇺🇸

Des Moines, Iowa, United States

Broadlawns Medical Center

🇺🇸

Des Moines, Iowa, United States

Trinity Regional Medical Center

🇺🇸

Fort Dodge, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center

🇺🇸

Iowa City, Iowa, United States

HaysMed

🇺🇸

Hays, Kansas, United States

Lawrence Memorial Hospital

🇺🇸

Lawrence, Kansas, United States

The University of Kansas Cancer Center - Olathe

🇺🇸

Olathe, Kansas, United States

Salina Regional Health Center

🇺🇸

Salina, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health

🇺🇸

Topeka, Kansas, United States

University of Kansas Health System Saint Francis Campus

🇺🇸

Topeka, Kansas, United States

Flaget Memorial Hospital

🇺🇸

Bardstown, Kentucky, United States

Saint Joseph Hospital

🇺🇸

Lexington, Kentucky, United States

Saint Joseph Hospital East

🇺🇸

Lexington, Kentucky, United States

Saint Joseph London

🇺🇸

London, Kentucky, United States

Cancer Center of Acadiana

🇺🇸

Lafayette, Louisiana, United States

Louisiana State University Health Science Center

🇺🇸

New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson

🇺🇸

New Orleans, Louisiana, United States

OSF Saint Francis Hospital and Medical Group

🇺🇸

Escanaba, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

🇺🇸

Grand Rapids, Michigan, United States

UP Health System Marquette

🇺🇸

Marquette, Michigan, United States

Corewell Health Reed City Hospital

🇺🇸

Reed City, Michigan, United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

🇺🇸

Saint Joseph, Michigan, United States

Munson Medical Center

🇺🇸

Traverse City, Michigan, United States

Essentia Health Saint Joseph's Medical Center

🇺🇸

Brainerd, Minnesota, United States

Minnesota Oncology - Burnsville

🇺🇸

Burnsville, Minnesota, United States

Mercy Hospital

🇺🇸

Coon Rapids, Minnesota, United States

Essentia Health - Deer River Clinic

🇺🇸

Deer River, Minnesota, United States

Essentia Health Saint Mary's - Detroit Lakes Clinic

🇺🇸

Detroit Lakes, Minnesota, United States

Essentia Health Cancer Center

🇺🇸

Duluth, Minnesota, United States

Saint Luke's Hospital of Duluth

🇺🇸

Duluth, Minnesota, United States

Fairview Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Essentia Health - Ely Clinic

🇺🇸

Ely, Minnesota, United States

Unity Hospital

🇺🇸

Fridley, Minnesota, United States

Essentia Health Hibbing Clinic

🇺🇸

Hibbing, Minnesota, United States

Essentia Health - International Falls Clinic

🇺🇸

International Falls, Minnesota, United States

Fairview Clinics and Surgery Center Maple Grove

🇺🇸

Maple Grove, Minnesota, United States

Minnesota Oncology Hematology PA-Maplewood

🇺🇸

Maplewood, Minnesota, United States

Saint John's Hospital - Healtheast

🇺🇸

Maplewood, Minnesota, United States

Abbott-Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

Hennepin County Medical Center

🇺🇸

Minneapolis, Minnesota, United States

Monticello Cancer Center

🇺🇸

Monticello, Minnesota, United States

New Ulm Medical Center

🇺🇸

New Ulm, Minnesota, United States

Essentia Health - Park Rapids

🇺🇸

Park Rapids, Minnesota, United States

North Memorial Medical Health Center

🇺🇸

Robbinsdale, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park

🇺🇸

Saint Louis Park, Minnesota, United States

Regions Hospital

🇺🇸

Saint Paul, Minnesota, United States

United Hospital

🇺🇸

Saint Paul, Minnesota, United States

Essentia Health Sandstone

🇺🇸

Sandstone, Minnesota, United States

Saint Francis Regional Medical Center

🇺🇸

Shakopee, Minnesota, United States

Lakeview Hospital

🇺🇸

Stillwater, Minnesota, United States

Essentia Health Virginia Clinic

🇺🇸

Virginia, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Rice Memorial Hospital

🇺🇸

Willmar, Minnesota, United States

Minnesota Oncology Hematology PA-Woodbury

🇺🇸

Woodbury, Minnesota, United States

Fairview Lakes Medical Center

🇺🇸

Wyoming, Minnesota, United States

Saint Louis Cancer and Breast Institute-Ballwin

🇺🇸

Ballwin, Missouri, United States

Saint Francis Medical Center

🇺🇸

Cape Girardeau, Missouri, United States

Parkland Health Center - Farmington

🇺🇸

Farmington, Missouri, United States

University Health Truman Medical Center

🇺🇸

Kansas City, Missouri, United States

Lake Regional Hospital

🇺🇸

Osage Beach, Missouri, United States

Mercy Clinic-Rolla-Cancer and Hematology

🇺🇸

Rolla, Missouri, United States

Phelps Health Delbert Day Cancer Institute

🇺🇸

Rolla, Missouri, United States

Heartland Regional Medical Center

🇺🇸

Saint Joseph, Missouri, United States

SSM Health Saint Louis University Hospital

🇺🇸

Saint Louis, Missouri, United States

Mercy Hospital South

🇺🇸

Saint Louis, Missouri, United States

Mercy Hospital Saint Louis

🇺🇸

Saint Louis, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

Sainte Genevieve County Memorial Hospital

🇺🇸

Sainte Genevieve, Missouri, United States

Mercy Hospital Springfield

🇺🇸

Springfield, Missouri, United States

CoxHealth South Hospital

🇺🇸

Springfield, Missouri, United States

Missouri Baptist Sullivan Hospital

🇺🇸

Sullivan, Missouri, United States

BJC Outpatient Center at Sunset Hills

🇺🇸

Sunset Hills, Missouri, United States

Benefis Sletten Cancer Institute

🇺🇸

Great Falls, Montana, United States

Community Hospital of Anaconda

🇺🇸

Anaconda, Montana, United States

Billings Clinic Cancer Center

🇺🇸

Billings, Montana, United States

Bozeman Health Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Great Falls Clinic

🇺🇸

Great Falls, Montana, United States

Logan Health Medical Center

🇺🇸

Kalispell, Montana, United States

Community Medical Center

🇺🇸

Scranton, Pennsylvania, United States

CHI Health Good Samaritan

🇺🇸

Kearney, Nebraska, United States

Carson Tahoe Regional Medical Center

🇺🇸

Carson City, Nevada, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

🇺🇸

Lebanon, New Hampshire, United States

Inspira Medical Center Vineland

🇺🇸

Vineland, New Jersey, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

Memorial Medical Center-Las Cruces

🇺🇸

Las Cruces, New Mexico, United States

Mary Imogene Bassett Hospital

🇺🇸

Cooperstown, New York, United States

Novant Health Colon and Rectal Clinic

🇺🇸

Clemmons, North Carolina, United States

Southeastern Medical Oncology Center-Clinton

🇺🇸

Clinton, North Carolina, United States

Durham VA Medical Center

🇺🇸

Durham, North Carolina, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

Southeastern Medical Oncology Center-Goldsboro

🇺🇸

Goldsboro, North Carolina, United States

Novant Health Breast Surgery - Greensboro

🇺🇸

Greensboro, North Carolina, United States

Margaret R Pardee Memorial Hospital

🇺🇸

Hendersonville, North Carolina, United States

Southeastern Medical Oncology Center-Jacksonville

🇺🇸

Jacksonville, North Carolina, United States

Novant Health Cancer Institute - Kernersville

🇺🇸

Kernersville, North Carolina, United States

Novant Health Cancer Institute - Mount Airy

🇺🇸

Mount Airy, North Carolina, United States

Novant Health Cancer Institute - Thomasville

🇺🇸

Thomasville, North Carolina, United States

Novant Health Forsyth Medical Center

🇺🇸

Winston-Salem, North Carolina, United States

Essentia Health Cancer Center-South University Clinic

🇺🇸

Fargo, North Dakota, United States

Strecker Cancer Center-Belpre

🇺🇸

Belpre, Ohio, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

Knox Community Hospital

🇺🇸

Mount Vernon, Ohio, United States

Mercy Health - Perrysburg Hospital

🇺🇸

Perrysburg, Ohio, United States

Mercy Health - Saint Anne Hospital

🇺🇸

Toledo, Ohio, United States

Mercy Hospital Oklahoma City

🇺🇸

Oklahoma City, Oklahoma, United States

Saint Alphonsus Cancer Care Center-Ontario

🇺🇸

Ontario, Oregon, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazleton

🇺🇸

Hazleton, Pennsylvania, United States

Geisinger Medical Oncology-Lewisburg

🇺🇸

Lewisburg, Pennsylvania, United States

Geisinger Cancer Services-Pottsville

🇺🇸

Pottsville, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Regional Cancer Center at Johnson City Medical Center

🇺🇸

Johnson City, Tennessee, United States

Ballad Health Cancer Care - Kingsport

🇺🇸

Kingsport, Tennessee, United States

Hendrick Medical Center

🇺🇸

Abilene, Texas, United States

STCC at DHR Health Institute for Research and Development

🇺🇸

Edinburg, Texas, United States

Doctor's Hospital of Laredo

🇺🇸

Laredo, Texas, United States

Dartmouth Cancer Center - North

🇺🇸

Saint Johnsbury, Vermont, United States

Ballad Health Cancer Care - Bristol

🇺🇸

Bristol, Virginia, United States

Chesapeake Regional Medical Center

🇺🇸

Chesapeake, Virginia, United States

Sovah Health Martinsville

🇺🇸

Martinsville, Virginia, United States

Sentara Norfolk General Hospital

🇺🇸

Norfolk, Virginia, United States

Hunter Holmes McGuire Veterans Administration Medical Center

🇺🇸

Richmond, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center

🇺🇸

Richmond, Virginia, United States

VCU Community Memorial Health Center

🇺🇸

South Hill, Virginia, United States

Sentara Princess Anne Hospital

🇺🇸

Virginia Beach, Virginia, United States

Duluth Clinic Ashland

🇺🇸

Ashland, Wisconsin, United States

SSM Health Dean Medical Group - Baraboo

🇺🇸

Baraboo, Wisconsin, United States

HSHS Sacred Heart Hospital

🇺🇸

Eau Claire, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay

🇺🇸

Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's

🇺🇸

Green Bay, Wisconsin, United States

SSM Health Dean Medical Group - Janesville

🇺🇸

Janesville, Wisconsin, United States

Gundersen Lutheran Medical Center

🇺🇸

La Crosse, Wisconsin, United States

SSM Health Dean Medical Group - South Madison Campus

🇺🇸

Madison, Wisconsin, United States

Cancer Center of Western Wisconsin

🇺🇸

New Richmond, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Oconto Falls

🇺🇸

Oconto Falls, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

🇺🇸

Sturgeon Bay, Wisconsin, United States

Essentia Health Saint Mary's Hospital - Superior

🇺🇸

Superior, Wisconsin, United States

Memorial Hospital of Sweetwater County

🇺🇸

Rock Springs, Wyoming, United States

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