An evaluation of HLA, Phagocytic function and Trace elements in cases of Sinusitis, Invasive Fungal Sinusitis and Non-Invasive Fungal Sinusitis
- Conditions
- Health Condition 1: J329- Chronic sinusitis, unspecified
- Registration Number
- CTRI/2019/11/021887
- Lead Sponsor
- AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
This project will be conducted at AIIMS, New Delhi after approval from ethical committee. Total 200 patients will be recruited in study, out of 200, 50 patients will be included with diagnosis of sinusitis, 50 patients will be included with diagnosis of non-invasive fungal sinusitis and 50 patients will be included with diagnosis of invasive fungal sinusitis. For control, 50 blood samples will be collected from healthy individuals. All patients will be diagnosing by existing protocol in the department of Otolaryngology Head and Neck Surgery for sinonasal fungal disease. The current departmental practice for sinusitis is based on Rhinology society guidelines. Rhinology society proposed major and minor criteria to diagnose sinusitis. Fungal sinusitis is present with history of symptoms similar to sinusitis along with features of surrounding tissue invasion like orbit and brain. Invasive and non invasive fungal sinusitis is diagnosed on the basis of clinic radiological presentation and final conformation is based on histopathology. In non invasive fungal sinusitis radiology shows presence of heterogeneous characteristic mass in nose and paranasal sinuses with or without surrounding bone erosion. In comparison to invasive fungal sinusitis surrounding plane are maintained in non invasive fungal sinusitis.
1- AGE BELOW 18 AND ABOVE 60
2-NOT WILLING FOR PARTICIPATIO
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This study aims to identify the relationship between genetic factors, phagocytic function and trace elements and their role in the formation of sinusitis which will help us understand the disease process better and identify factors that affect aggressiveness of the disease. This study may direct us to establish treatment protocol for fungal sinusitis. <br/ ><br> <br/ ><br>Timepoint: 1-Sample collection- 20 months <br/ ><br>2-Data evaluation- 4 months <br/ ><br>
- Secondary Outcome Measures
Name Time Method nilTimepoint: nil