A study to evaluate the effect of dexmedetomidine on blood pressure and heart rate of patients during a surgical procedure where pins are drilled inside the skull while removing a part of it.
Phase 4
- Conditions
- Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
- Registration Number
- CTRI/2020/07/026325
- Lead Sponsor
- Dr Nandini Phukan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA I and II
2.Elective surgery
3.Pre operative GCS 15
4.Patients giving valid consent
Exclusion Criteria
1.Pre operative heart rate less than 45
2.Pregnancy
3.Known allergy to dexmedetomidine
4.Second or third degree haeart block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the effect of iv inj dexmedetomidine in attenuating the haemodynamic response(SBP,DBP,MAP,HR) to skull pin holder application during craniotomyTimepoint: At the time of pin insertion,1,5,10,15 mins after pin insertion
- Secondary Outcome Measures
Name Time Method To compare the plasma glucose level before and after pin insertionTimepoint: 15 mins before the administration of inj dexmedetomidine or placebo(baseline) and 30 and 60 mins after pin insertion;To determine the effect of iv inj dexmedetomidine in attenuating the haemodynamic response(SBP,DBP,MAP,HR) during laryngoscopy and intubation <br/ ><br>Timepoint: After giving drug or placebo,after intubation <br/ ><br>