Does resistance exercise with/without a nutrition supplement improve bone and muscle strength in women?

Not Applicable

Completed

• Conditions: Osteoporosis and sarcopenia; Musculoskeletal Diseases

• Registration Number: ISRCTN12419961
• Lead Sponsor: eeds Beckett University

Brief Summary

2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/37323260/ case study of one patient in this study (added 05/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-07-07
• Study Completion: 2018-06-30
• Last Update Posted: 18 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

1. Community-dwelling women aged 65 or over
2. Not currently engaged in upper body exercise training (within last 6 months)
3. Not using any medications for osteoporosis and not using any medications that can affect bone metabolism
4. Do not have an underlying disease that impairs bone metabolism, such as hyper/hypoparathyroidism, renal disease and malabsorptive conditions

Exclusion Criteria

1. Currently engaged in upper body exercise training (or within last 6 months)
2. Using medications for osteoporosis
3. Using any medications that can affect bone metabolism
4. Have an underlying disease that impairs bone metabolism, such as hyper/hypoparathyroidism, renal disease and malabsorptive conditions
5. Recent forearm fracture (within the last 6 months)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Biochemical markers (serum measures of osteocalcin (bone turnover), C-terminal telopeptide (bone resorption), pro-collagen 1 intact N-terminal (bone formation), 25[OH] D (vitamin D), insulin-like growth factor-1), measured at 0 and 3 months<br>2. Bone mineral density of the forearm, measured using DXA at 0, 3 and 6 months

Secondary Outcome Measures

Name	Time	Method
1. Bone mineral density of the spine and hip, measured using DXA at 0 and 6 months<br>2. Lean and fat mass, measured using DXA at 0, 3 and 6 months<br>3. Senior Fitness Test (hand grip, sit to stand test, gait speed over 6 m, and 6 minute walk test), measured at 0, 3 and 6 months<br>4. Wrist strength, measured using 30 sec wrist curl test at 0, 3 and 6 months<br><br>Control outcomes<br>1. Lifetime physical activity and physical activity in the last 12 months, measured using the bone specific physical activity questionnaire at 0, 3 and 6 months<br>2. Dietary evaluation using a self-report 3-day diary at 0, 6, 12 and 18 weeks