Efficacy of statin therapy on arterial wall inflammation in patients with Chronic Kidney Disease

Completed

Conditions: arterial wall thickening
atherosclerosis
10038430
10003216

Registration Number: NL-OMON45991

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

1. Aged 50 years or older
2. CKD stages 3 and 4 (eGFR: 15-60 ml min-1)

Exclusion Criteria

1. Malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.
2. Standard contra-indications to 18F-FDG PET, and CT based on physicians experience and current practices
3. Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.
4. Planned radiation exposure in the next year due to participation in a research project with radiation exposure or for clinical reasons.
5. Clinical signs of acute infection and/or CRP>10
6. History of MI/Stroke or known coronary artery disease
7. Already receiving lipid lowering treatment

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in target-to-background ratio (TBR) in patients with CKD before and<br /><br>after statin therapy</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Monocyte subtyping will be assessed by FACS analysis<br /><br>- Monocyte expression of genes involved in inflammation<br /><br>- Trans endothelial migration will be assessed according to standard procedures<br /><br>at Sanquin as described in van Buul et al (16).<br /><br>- In vitro cytokine production will be assessed using isolated monocytes of<br /><br>subjects. Monocytes will be stimulized with LPS, assessing production of<br /><br>inflammatory cytokines (Il6, TNF*)<br /><br>- Epigenetic changes will be assessed by looking at H3K4 methylation at target<br /><br>genes assessed in the previous steps.</p><br>