Efficacy of Statin Therapy on Atherosclerotic Inflammation in Patients with Ankylosing Spondylitis

Completed

• Conditions: Atherosclerosis; Bechterew; 10003216; 10003816

• Registration Number: NL-OMON40566
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Subjects with AS
- Age: *18 years
- Diagnosis of AS (following the 1984 Modified New York Criteria for ankylosing Spondylitis (16)) + disease duration since start of first symptoms for a period of more than 3 years.

Exclusion Criteria

Subjects may not enter this study if they meet the following criteria
-BMI > 30.
-history of diabetes mellitus/insulin use
-hypertension/use of blood pressure lowering medication
-use of statins or contraindications for the use of statins
-history of cardiovascular events
-proven or suspected bacterial infections.
-use of anti-inflammatory medication from group biologicals

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Effect of 3 months statin therapy on vessel wall FDG uptake. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Medical history, medication use, prior use of DMARD*s and biologicals<br /><br>- Demographic parameters (age, race, gender)<br /><br>- Cardiovascular risk factors<br /><br>- Inflammatory parameters: CRP, hsCRP, BSE, IL1, Il6, TNF, IL17 </p><br>