Comparison of Reversal of Neuromuscular Blockade With Sugammadex Versus Neostigmine Plus Glycopyrolate in Patients Undergoing Burn Surgery
- Registration Number
- NCT03513406
- Lead Sponsor
- University of Kansas Medical Center
- Brief Summary
The purpose of this study is to learn if there is a difference in recovery time when using sugammadex versus neostigmine. The researchers also hope to add further knowledge and data to the safety of using sugammadex in burn patients who are hypermetabolic.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
Inclusion Criteria
- Undergoing burn surgery under general anesthesia
Exclusion Criteria
- Patients without a non-burned upper extremity
- Renal insufficiency or failure
- Sensitivity or hypersensitivity reaction to sugammadex
- Liver impairment, neuromuscular degenerative disease or dependence on drugs or alcohol
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sugammadex Sugammadex Muscle relaxant reversal will be attained with sugammadex 2 mg/kgm IV. Neostigmine Neostigmine Muscle relaxant reversal will be attained with neostigmine 50 mcg/kgm plus glycopyrrolate10 mcg/kgm IV. Neostigmine Glycopyrrolate Muscle relaxant reversal will be attained with neostigmine 50 mcg/kgm plus glycopyrrolate10 mcg/kgm IV.
- Primary Outcome Measures
Name Time Method Time to return to a 90% Train of Four (TOF) neuromuscular twitch Within 24 hours after surgery
- Secondary Outcome Measures
Name Time Method Time to discharge from the operating room Within 24 hours after surgery Time to endotracheal extubation Within 24 hours after surgery
Trial Locations
- Locations (1)
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States