Open Lung Approach During General Anaesthesia to Prevent Post-Operative Pulmonary Complications
- Conditions
- Postoperative Complications
- Registration Number
- NCT00426790
- Lead Sponsor
- Universit脿 degli Studi dell'Insubria
- Brief Summary
The hypothesis of this study is that the "Open lung approach" ( recruitment and PEEP) during general anaesthesia reduces atelectasis formation and improves respiratory function in the immediate post-operative period after major abdominal surgery.
This is a prospective, randomized, controlled clinical-trial,performed in patients undergoing major abdominal surgery, to compare the effects on the post-operative pulmonary complications of two different intraoperative ventilatory strategies during general anaesthesia: 1- Control Group: PEEP 0 cmH2O without recruitment manoeuvre; 2- Treatment Group:recruitment manoeuvre (after intubation and before extubation) and PEEP 10 cmH2O In the post-operative period the following variables will be recorded at the first, third and fifth postoperative day: 1- Gas-exchange in air; 2- Chest X-ray for atelectasis evaluation; 3- signs of pulmonary complication (cough, secretions, dyspnea, thoracic pain)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
- Patients with ASA 1, 2 and 3
- Age higher than 18 years
- Major abdominal surgery
- General anesthesia
- COPD with FEV1 lower than 50%
- Ischemic cardiopathy
- Loco-regional anesthesia alone
- Minor abdominal surgery
- Laparoscopic surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ospedale di Circolo e Fondazione Macchi
馃嚠馃嚬Varese, Italy