Open-lung Ventilatory Approach With Positive End-expiratory Pressure Titrated to Lowest Driving Pressure in Cardiac Surgery Patients

Fundación para la Investigación del Hospital Clínico de Valencia1 site in 1 country60 target enrollmentJuly 10, 2017

ConditionsLung Collapse

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Lung Collapse
Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia
Enrollment: 60
Locations: 1
Primary Endpoint: driving pressure
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.

Registry

clinicaltrials.gov

Start Date

July 10, 2017

End Date

February 2019

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Fundación para la Investigación del Hospital Clínico de Valencia

Responsible Party

Principal Investigator

Carlos Ferrando

Principal investigador

Fundación para la Investigación del Hospital Clínico de Valencia

Eligibility Criteria

Inclusion Criteria

•Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)

Exclusion Criteria

•i) age \<18yr or \>80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index \>35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.

Outcomes

Primary Outcomes

driving pressure

Time Frame: intraoperative

The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications