euromuscular electrical stimulation to enhance the exercise benefits for muscle functions during spaceflight

Not Applicable

Recruiting

Conditions: M62.5
Muscle wasting and atrophy, not elsewhere classified

Registration Number: DRKS00032106

Lead Sponsor: niversität Trieste

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 16

Inclusion Criteria

Astronauts from ESA, NASA, the Japanese or Canadian space agencies flying to the ISS.

Exclusion Criteria

- Subjects with ferromagnetic metal implants, pacemakers or electronic materials cannot be included in the study due to the MRI scan
- Previous head surgery with metal implants
- Claustrophobia
- Previous knee surgery or ligament injuries
- Personal or family history of epilepsy, uncontrolled high blood pressure, bleeding tendency, use of aspirin or warfarin, impaired blood clotting, history of nerve, muscular or skeletal disorders of the leg
- Allergies to kinesiology tape, stickers, electrode gel or Aquasonic ultrasound gel
- Cardiac diseases
- Pregnant women
- MRI cannot be performed on persons with:
Implanted pacemakers
Intracranial aneurysm clips
Cochlear implants
Certain prosthetic devices
Implanted drug infusion pumps
Neurostimulators
Bone growth stimulators
Certain intrauterine contraceptive devices (e.g. with iron-based metal)
All other types of iron-based metal implants.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurements before and immediately after spaceflight of: <br>- Muscle neuromuscular functions (muscle strength, fatigue resistance, voluntary activation capacity, motor unit function), muscle volume and architecture (MRI) <br>- Muscle perfusion (SO2, blood flow, Hb content) measured with NIRS and O2C <br>- Maximum oxygen uptake (V'O2) and maximum CO2 release (V'CO2) <br>- Blood analyses: circulating myokines, microRNAs, inflammatory and angiogenesis biomarkers, parameters of neuromuscular interaction, muscle physiology, etc. <br>- Questionnaires (muscular symptoms, previous diseases etc.)

Secondary Outcome Measures