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临床试验/NCT01918163
NCT01918163Unknown3 期

Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

Hillel Yaffe Medical Center2 个研究点 分布在 1 个国家目标入组 55 人开始时间: 2013年9月最近更新:
适应症

试验速览

阶段
3 期
入组人数
55
试验地点
2
主要终点
pregnancy

研究概览

简要总结

Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.

Minor data is available regarding the influence on male sperm.

详细描述

Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Supportive Care
盲法
None

入排标准

年龄范围
20 Years 至 60 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • TMC of less than 5 million spermatogonia in native sperm and morphology less than 4% by Kruger criteria.

排除标准

  • sensitivity to Pomegranate

结局指标

主要结局

pregnancy

时间窗: 24 month

次要结局

  • ROS (reactive oxidative stress )and Interleukins level in semen fluid(12 weeks)

研究者

申办方类型
Other Gov
责任方
Sponsor

研究点 (2)

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