Cognitive Functions in Adults with Sickle Cell Disease and Cognitive Complaints: Neuropsychological Assessment and Links to Demographic, Clinical, Biological, Neuroradiological Outcomes and Validation of a Cognitive Assessment Tool.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- BEARNI questionnaire
研究概览
简要总结
Sickle cell disease (SCD) is an inherited blood disorder. Symptoms include acute and chronic complications. Due to progress in SCD care, patients with SCD are living longer than before and we focus more attention in chronic complications.
Children with SCD experience worse cognitive functions than healthy children, and fewer is known about cognitive functions in adults. Studies suggest lower cognitive performance in SCD, mostly in executive functions and processing speed, but the biological and anatomical substrates of cognitive decline are not yet well established in SCD. Often times, cognitive impairments and cerebral disorders are not diagnosed and treated in adults with SCD.
The main objective of this study is to propose a deep neuropsychological assessment in adults with SCD and cognitive complaints and to highlight links between cognitive functions and clinical, biological and neuroradiological markers. The hypothesis of this study is that cognitive functions are associated with severity of the SCD, with bood abnormalities, with MRI markers and Transcranial Doppler (TCD) markers of cerebrovascular disease. The secondary objective of this study is to validate a brief cognitive assessment tool (BEARNI tool) in adults with SCD.
This study is an observational cross-sectional study that will enroll adults with SCD and cognitive complaint.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old
- •Sickle cell anemia (homozygous SS or heterozygous SC, Sβ0, S/C, Sβ+)
- •In steady state (without vaso-occlusive crisis or acute chest syndrome at the time of measurements)
- •Presence of spontaneous cognitive complaint or requested by the physician.
- •Good command of the French language (native language or not)
- •No objection to participate in the study
- •Affiliated patient or beneficiary of social security scheme
排除标准
- •Patient not compliant in the management of his disease
- •Patient participating in another interventional research protocol that may interfere with this protocol (according to investigator's judgment)
- •Language barrier
- •Pregnancy or breast feeding
- •MRI contraindication
- •Patient under guardianship , curatorship or justice
- •Inability to express non-opposition
结局指标
主要结局
BEARNI questionnaire
时间窗: Day 0
Cognitive performance will be evaluated by a large neuropsychological assessment. The cognitive score will be interpreted as raw scores, z-score adjusted for level of education, age, and sex, according to the tests and binarized into two categories (normal versus pathological performances)
次要结局
未报告次要终点